Serum Factors Involved in Beta-Cell Protection Against Glucolipotoxicity

• Grant number: 19/04233-6
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: May 01, 2019
• End date: April 30, 2022
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Principal Investigator: Alicia Juliana Kowaltowski
• Grantee: Ana Cláudia Munhoz Bonassa
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID

Abstract

We recently demonstrated that sera from lean calorically-restricted rats can protect beta cells, increasing glucose-sensitive insulin release under both normal culture conditions and glucolipotoxicity. The identification of molecular factors in the sera from lean animals that mediate this protective effect is of interest, since this could be a new therapeutic approach in the treatment of type II diabetes, and is the central aim of this post-doctoral fellowship.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SERNA, JULIAN D. C.; AMARAL, ANDRESSA G.; CALDEIRA DA SILVA, CAMILLE C.; MUNHOZ, ANA C.; VILAS-BOAS, ELOISA A.; MENEZES-FILHO, SERGIO L.; KOWALTOWSKI, ALICIA J.. Regulation of kidney mitochondrial function by caloric restriction. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 323, n. 1, p. 15-pg., 2022-07-01. (19/05226-3, 19/04233-6, 13/07937-8, 20/06970-5)