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The envolviment of the PPAR alpha nuclear receptor, on physical exercise protector effects against inflammation ANS hepatic steatosis induced for hGH fat diet

Grant number: 13/10861-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): September 01, 2013
Effective date (End): August 31, 2015
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal Investigator:José Cesar Rosa Neto
Grantee:Helena Angélica Pereira Batatinha
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Obesity is the disease with the highest number of cases in progress in recent years. This disorder usually associated with excessive intake of carbohydrates and lipids, is related to the development of chronic diseases such as hypertension, dyslipidemia, type 2 diabetes mellitus (T2DM), in all these co-morbidities there is an increase chronic systemic inflammation, leading to a decrease in expectation and quality of life. Obesity and insulin resistance promote several changes in liver functions related to fatty acids(FA) metabolism and favor the non-alcoholic steatosis (NASH) that it is an ectopic triglyceride deposition in hepatocytes parenchyma (Tilg Moschen and 2008; di Minno, Russolillo et al. 2012). A main treatments, today, to NASH is based on calorie restriction diet and physically active lifestyle. Exercise is capable of activate the AMP-activated protein kinase (AMPK). This protein complex is responsible for increasing the oxidative metabolism by stimulating lipolytic gene expression and inhibiting lipogenic genes expression. Furthermore, AMPK activates the Peroxisome proliferator-activated receptor (PPARs) (Canto and Auwerx 2010). PPARs are transcription factors of the nuclear receptor family that control the expression of genes involved in glucose and lipid metabolism. Our objective is to verify whether the beneficial effects of physical training on metabolism and liver inflammation are dependent on PPAR-alpha. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVEIRA, LOREANA S.; PIMENTEL, GUSTAVO D.; SOUZA, CAMILA O.; BIONDO, LUANA A.; TEIXEIRA, ALEXANDRE ABILIO S.; LIMA, EDSON A.; BATATINHA, HELENA A. P.; ROSA NETO, JOSE C.; LIRA, FABIO S.. Effect of an acute moderate-exercise session on metabolic and inflammatory profile of PPAR- knockout mice. Cell Biochemistry and Function, v. 35, n. 8, p. 510-517, . (13/09367-4, 14/01246-6, 13/10861-3, 13/04765-1, 13/25310-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BATATINHA, Helena Angélica Pereira. Aerobic Exercise decreases NAFLD, but promotes liver inflammation in PPAR-alpha knockout mice via PPAR-gamma inhibition.. 2015. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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