Effect of maternal and paternal supplementation with antioxidant in pulmonary inflammatory process of the offspring of mice

• Grant number: 19/02679-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: May 01, 2019
• End date: January 05, 2023
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Maria Notomi Sato
• Grantee: Ricardo Wesley Alberca Custódio
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 21/09161-3 - The role of innate immune accessory cells in Th2 differentiation, BE.EP.PD

Abstract

Pregnancy is considered a period of increased susceptibility to infections due to the differential immunological conditions generated in fetal development. During pregnancy bacterial infections can lead to complications in the mother and the fetus, leading to early conceptions and abortion, being considered a serious maternal-child health and economic-social burden. Therefore, prophylactic and therapeutic interventions for infections that are not dangerous during pregnancy needs to be investigated. The maternal consumption of flavonoid naringenin during gestation does not show deleterious effects to the offspring and previous studies in the non-pregnant condition show an anti-inflammatory potential, in addition to its broad spectrum of action in metabolic syndromes. For this purpose, we will use a model of cervical and intrauterine inflammation induced by lipopolysaccharide during pregnancy of mice supplemented or not with naringenin (NAR). Additionally NAR supplementation, including breastfeeding, will investigate the effects of lung inflammatory response on offspring. Although most research focuses on the maternal importance on the immune system and health of offspring, recent researches has shown paternal influence. Among the mechanisms that may explain the paternal influence in the offspring are the MicroRNAs (miRNAs) of the semen. The miRNAS are small molecules of non-coding RNA, which regulate the expression of several genes and can be modified by dietary supplementation. Therefore, we will investigate the effect of maternal or paternal supplementation with NAR in the development of two clinically relevant respiratory syndromes during childhood: neutrophilic asthma and acute respiratory distress syndrome. The effect of maternal supplementation during pregnancy and/or breastfeeding on the development of both respiratory syndromes and the mechanisms responsible for the possible suppression of the inflammatory response will be evaluated. In parallel, we will analyze the effect of paternal NAR consumption prior to fertilization on the inflammatory response of the offspring and the changes in semen miRNAs. The present project is justified in understanding the effects of maternal and paternal supplementation on the development of inflammatory responses of the offspring, and may provide subsidies for the elaboration of prophylactic interventions. (AU)

Scientific publications

(22)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALBERCA, RICARDO WESLEY; TEIXEIRA, FRANCIANE MOURADIAN EMIDIO; BESERRA, DANIELLE ROSA; DE OLIVEIRA, EMILY ARAUJO; ANDRADE, MILENA MARY DE SOUZA; PIETROBON, ANNA JULIA; SATO, MARIA NOTOMI. Perspective: The Potential Effects of Naringenin in COVID-19. FRONTIERS IN IMMUNOLOGY, v. 11, SEP 25 2020. (19/02679-7, 17/18199-9, 18/18230-6)

EDITH SOLIS-CASTRO, MARIA; JARAMILLO-CORRALES, ALEX; GONZALEZ SEMINARIO, ROMMELL VEINTIMILLA; JANAMPA GRADOS, NOEMI; MAMANI PILCO, IDANIA EDITH; VARGAS QUISPE, KARINA ELIZABETH; LA TORRE ROSILLO, LENIN YONEL; VASQUEZ DOMINGUEZ, MARIO NEYSER; ENRIQUEZ CUSI, DAVID TEODORO; MINAYA, PERCY; et al. Effectiveness of the Inactivated SARS-CoV-2 (Vero Cell) Vaccine in Peruvian Health Workers. LIFE-BASEL, v. 12, n. 9, p. 17-pg., 2022-09-01. (19/02679-7)

ALBERCA, RICARDO WESLEY; BENARD, GIL; ALBERCA, GABRIELA GAMA FREIRE; SATO, MARIA NOTOMI. SARS-CoV-2 infection in liver transplant recipients: A complex relationship. WORLD JOURNAL OF GASTROENTEROLOGY, v. 27, n. 44, NOV 28 2021. (19/02679-7, 20/13148-0)

ALBERCA, RICARDO WESLEY; SOLIS-CASTRO, ROSA LILIANA; SOLIS-CASTRO, MARIA EDITH; CARDOSO, FERNANDA; DUARTE, ALBERTO JOSE DA SILVA; OLIVEIRA, LUANA DE MENDONCA; PEREIRA, NATALLI ZANETE; GOZZI-SILVA, SARAH CRISTINA; DE OLIVEIRA, EMILY ARAUJO; AOKI, VALERIA; et al. Platelet-Based Biomarkers for Diagnosis and Prognosis in COVID-19 Patients. LIFE-BASEL, v. 11, n. 10, OCT 2021. (19/02679-7, 20/13148-0, 19/22448-0, 17/18199-9)

GOZZI-SILVA, SARAH CRISTINA; BENARD, GIL; ALBERCA, RICARDO WESLEY; YENDO, TATIANA MINA; EMIDIO TEIXEIRA, FRANCIANE MOURADIAN; OLIVEIRA, LUANA DE MENDONCA; BESERRA, DANIELLE ROSA; PIETROBON, ANNA JULIA; DE OLIVEIRA, EMILY ARAUJO; CALVIELLI CASTELO BRANCO, ANNA CLAUDIA; et al. SARS-CoV-2 Infection and CMV Dissemination in Transplant Recipients as a Treatment for Chagas Cardiomyopathy: A Case Report. TROPICAL MEDICINE AND INFECTIOUS DISEASE, v. 6, n. 1, MAR 2021. (18/18230-6, 17/18199-9, 19/02679-7, 19/26928-6, 19/22448-0)

ALBERCA, GABRIELA GAMA FREIRE; ALBERCA, RICARDO WESLEY. COVID-19-vaccinated plasma treatment for COVID-19 patients?. Influenza and Other Respiratory Viruses, v. 15, n. 4, MAR 2021. (19/02679-7)

ALBERCA, RICARDO WESLEY; RAMOS, YASMIM ALEFE LEUZZI; PEREIRA, NATALLI ZANETE; BESERRA, DANIELLE ROSA; BRANCO, ANNA CLAUDIA CALVIELLI CASTELO; ORFALI, RAQUEL LEAO; AOKI, VALERIA; DUARTE, ALBERTO JOSE DA SILVA; SATO, MARIA NOTOMI. Long-term effects of COVID-19 in diabetic and non-diabetic patients. FRONTIERS IN PUBLIC HEALTH, v. 10, p. 5-pg., 2022-08-15. (20/13148-0, 19/02679-7, 19/25119-7)

ALBERCA, GABRIELA GAMA FREIRE; ALBERCA, RICARDO WESLEY. E-cigarettes in the COVID-19 era. ANNALS OF THORACIC MEDICINE, v. 16, n. 2, p. 2-pg., 2021-04-01. (19/02679-7)

ALBERCA, RICARDO WESLEY; YENDO, TATIANA; AOKI, VALERIA; SATO, MARIA NOTOMI. Asthmatic patients and COVID-19: Different disease course?. ALLERGY, v. 76, n. 3, p. 3-pg., 2021-03-01. (17/18199-9, 19/02679-7)

ALBERCA, RICARDO WESLEY; YENDO, TATIANA; AOKI, VALERIA; SATO, MARIA NOTOMI. Asthmatic patients and COVID-19: Different disease course?. ALLERGY, v. 76, n. 3, SI, p. 963-965, MAR 2021. (19/02679-7, 17/18199-9)

ALBERCA, RICARDO WESLEY; DE SOUZA ANDRADE, MILENA MARY; CALVIELLI CASTELO BRANCO, ANNA CLAUDIA; PIETROBON, ANNA JULIA; PEREIRA, NATALLI ZANETE; FERNANDES, IARA GRIGOLETTO; OLIVEIRA, LUANA DE MENDONCA; EMIDIO TEIXEIRA, FRANCIANE MOURADIAN; BESERRA, DANIELLE ROSA; DE OLIVEIRA, EMILY ARAUJO; et al. Frequencies of CD33+CD11b+HLA-DR-CD14-CD66b+and CD33+CD11b+HLA-DR-CD14+CD66b-Cells in Peripheral Blood as Severity Immune Biomarkers in COVID-19. FRONTIERS IN MEDICINE, v. 7, OCT 14 2020. (19/02679-7, 17/18199-9, 19/26928-6, 18/18230-6, 19/22448-0)

ALBERCA, GABRIELA GAMA FREIRE; CARDOSO, NAIANE SAMIRA SOUZA; ALBERCA, RICARDO WESLEY. Could immune activation cause pancreatitis in COVID-19 patients?. TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY, MAR 2021. (19/02679-7)

ALBERCA, RICARDO WESLEY; GOMES, ELIANE; RUSSO, MOMTCHILO. CpG-ODN Signaling via Dendritic Cells-Expressing MyD88, but Not IL-10, Inhibits Allergic Sensitization. VACCINES, v. 9, n. 7, JUL 2021. (13/24694-1, 19/02679-7)

ALBERCA, G. G. F.; ALBERCA, R. W.. Few insights on the post-COVID-19 problem. BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, v. 122, n. 6, p. 438, 2021. (19/02679-7)

ALBERCA, G. G. F.; ALBERCA, R. W.. Nutrition and the microbiota post-COVID-19. SAUDI JOURNAL OF GASTROENTEROLOGY, v. 27, n. 2, p. 111-112, MAR-APR 2021. (19/02679-7)

ALBERCA, RICARDO WESLEY. Asthma endotypes and COVID-19. JOURNAL OF ASTHMA, v. 58, n. 11, p. 1424-1425, NOV 2 2021. (19/02679-7)

ALBERCA, RICARDO WESLEY; PEREIRA, NATALLI ZANETE; OLIVEIRA, LUANDA MARA DA SILVA; GOZZI-SILVA, SARAH CRISTINA; SATO, MARIA NOTOMI. Pregnancy, Viral Infection, and COVID-19. FRONTIERS IN IMMUNOLOGY, v. 11, JUL 7 2020. (19/22448-0, 19/02679-7, 19/07976-0)

ALBERCA, GABRIELA GAMA FREIRE; ALBERCA, RICARDO WESLEY. What is the long-term clinical significance of anti-SARS-CoV-2-specific IgG?. Influenza and Other Respiratory Viruses, v. 15, n. 3, NOV 2020. (19/02679-7)

ALBERCA, RICARDO WESLEY; LIMA, JULIA CATALDO; DE OLIVEIRA, EMILY ARAUJO; GOZZI-SILVA, SARAH CRISTINA; LEUZZI RAMOS, YASMIM ALEFE; DE SOUZA ANDRADE, MILENA MARY; BESERRA, DANIELLE ROSA; OLIVEIRA, LUANA DE MENDONCA; CALVIELLI CASTELO BRANCO, ANNA CLAUDIA; PIETROBON, ANNA JULIA; et al. COVID-19 Disease Course in Former Smokers, Smokers and COPD Patients. FRONTIERS IN PHYSIOLOGY, v. 11, JAN 27 2021. (19/02679-7, 17/18199-9)

ALBERCA, RICARDO WESLEY; OLIVEIRA, LUANA DE MENDONCA; BRANCO, ANNA CLAUDIA CALVIELLI CASTELO; PEREIRA, NATALLI ZANETE; SATO, MARIA NOTOMI. Obesity as a risk factor for COVID-19: an overview. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, v. 61, n. 13, JUN 2020. (19/02679-7)

ALBERCA, RICARDO WESLEY. Animal models and COVID-19: Mechanism and comorbidities. Respirology, v. 26, n. 6, p. 2-pg., 2021-04-13. (19/02679-7)

BRANCO, ANNA CLAUDIA CALVIELLI CASTELO; SATO, MARIA NOTOMI; ALBERCA, RICARDO WESLEY. The Possible Dual Role of the ACE2 Receptor in Asthma and Coronavirus (SARS-CoV2) Infection. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 10, p. 6-pg., 2020-09-23. (19/02679-7)