Development of functionalized calcium phosphate particles for use in remineralizing restorative composites

• Grant number: 19/01701-9
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: May 01, 2019
• End date: October 31, 2021
• Field of knowledge: Health Sciences - Dentistry - Dental Materials
• Principal Investigator: Roberto Ruggiero Braga
• Grantee: Bruna Marin Fronza
• Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

This project proposes the synthesis of calcium phosphate particles functionalized with monomers containing phosphate groups (methacryloxyethyl phosphate, MOEP; and 10-methacrylyloxydecyl dihydrogen phosphate, MDP) with the objective of producing calcium and phosphate ion-releasing particles with good dispersion and chemical interaction with resin matrixes based on dimethacrylates. These particles will be used in the development of composites with mechanical properties compatible with the clinical use as restorative material in posterior teeth, and capable of promoting dentin remineralization. This project is divided into three phases. In Phase 1, dicalcium phosphate (DCPD) particles will be synthesized and characterized with respect to the presence of the functional monomer, surface area, size and morphology. In Phase 2, particles having desirable size and functionalization characteristics will be incorporated into a resin matrix in combination with conventional fillers to produce composites. These materials will be tested for mechanical properties and ion release. Finally, in Phase 3, the materials showing the best behavior in the previous phase will be tested as restoration in vitro regarding its dentin remineralization potential.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VILELA, HANDIALLY SANTOS; RODRIGUES, MARCELA CHARANTOLA; FRONZA, BRUNA MARIN; TRINCA, RAFAEL BERGAMO; VICHI, FLAVIO MARON; BRAGA, ROBERTO RUGGIERO. Effect of Temperature and pH on Calcium Phosphate Precipitation. Crystal Research and Technology, v. 56, n. 12, OCT 2021. (20/13983-6, 18/21023-2, 19/04737-4, 19/01701-9)

CAMPOS, AMANDA LOPES; FRONZA, BRUNA MARIN; RODRIGUES, MARCELA CHARANTOLA; SOUZA CHIARI, MARINA DAMASCENO E.; BRAGA, ROBERTO RUGGIERO. Influence of the calcium orthophosphate:glass ratio and calcium orthophosphate functionalization on the degree of conversion and mechanical properties of resin-based composites. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 111, n. 1, p. 8-pg., 2023-01-01. (19/01701-9, 20/04537-2)