Morphological and metabolic comparative study between carcinoma ex pleomorphic adenoma of lacrimal and salivar glands

• Grant number: 19/10788-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2019
• End date: May 31, 2020
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Fernanda Viviane Mariano Brum Corrêa
• Grantee: Natália de Magalhães Rodrigues
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 15/07304-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry, AP.JP

Abstract

The Pleomorphic Adenoma (PA) is the most frequent benign tumor in the salivary glands, but it can also be found less frequently in other localities as in the lacrimal glands. While benign, these tumors have the tendency to recur and undergo malignant transformation, if it is not completely removed, malignant transformation to Carcinoma Ex Pleomorphic Adenoma (CXPA) may occur. CXAP is an aggressive neoplasm and it is believed that the process of malignization of a PA is a result of the accumulation of genetic and metabolic alterations. The process of malignization of a PA is poorly elucidated and important investigations of metabolic and genetic alterations in PA e CXPA are important. This application is part of a budget of grant (Young Researcher, Proc. 2015 / 07304-0), where we are studying a group of PAs and CXAPs (subdivided according to the histological type and degree of (glycogenesis, lipogenesis) through immunohistochemical and gene expression markers. This project will correlate the findings of a prior study of exome and CGH-array pathways whose evaluation is in the final phase. As a part of the Scientific Initiation Program, we will perform the investigation of the metabolic pathways by immunohistochemistry carrying out a complementary study that aims to help in understanding the results already found. Thus, this project aims to compare the metabolic alterations of tumors in the lacrimal glands with salivary glands, through the expression of GLUT-1 and HIF-1± and the correlation with cytoplasmic lipid droplets (lipogenesis). The aims of this study are to add knowledge regarding the metabolic factors of this neoplasm related to the tumor environment and anatomical site.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE LIMA-SOUZA, REYDSON ALCIDES; RODRIGUES, NATALIA DE MAGALHAES; SCARINI, JOAO FIGUEIRA; SOBRAL SILVA, MARIO FERNANDEZ; TINCANI, ALFIO JOSE; ABU EGAL, ERIKA SAID; ALTEMANI, ALBINA; MARIANO, FERNANDA VIVIANE. Metabolic alterations in carcinoma ex pleomorphic adenoma development of lacrimal glands. INTERNATIONAL OPHTHALMOLOGY, NOV 2021. (19/06809-2, 19/10788-0, 15/07304-0, 19/09419-0)