Evaluation of toxicity and antineoplastic action in BALB/c mice inoculated with Ehrlich's Tumor treated with superparamagnetic nanoparticles

• Grant number: 18/12219-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: July 01, 2019
• End date: June 30, 2022
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Fernando Luiz Affonso Fonseca
• Grantee: Camila dos Santos Chagas
• Host Institution: Centro Universitário FMABC (FMABC). Santo André , SP, Brazil

Abstract

Currently there is a wide range of drugs for the different types of cancer, however, research is still needed on the development of new therapeutic forms for the treatment of cancerous tumors, given the various side effects caused by the drugs that are available in the market. In view of this need, the present project is focused on the study of drug carrier devices, such as magnetite (Fe3O4) or magnetite (g-Fe2O3) superparamagnetic nanoparticles (NPs), due to the promising results found in the literature. The NPs will be obtained by the method of coprecipitation of Fe salts and will be functionalized with a series of hydrophilic, biocompatible molecules, such as amino acids, polymers, functionalized silicas, among others. These nanosites will be characterized in terms of structure, morphology and magnetic properties by various techniques. The second part of this project will focus on the use of these systems as carrier vehicles for photoactive molecules, drugs (anti-inflammatories and antibiotics) and molecules that act as in vivo antitumor agents, such as LASSBio-1735 which has shown promising results in recent studies.The evaluation of the antineoplastic action will be made based on the relation of the gene expression of inflammatory markers and oxidative stress, tumor growth and toxicity evaluation. Balb/c mice inoculated with Ehrlich tumor cells will be used. These animals will be treated in different periods and groups. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARTINS, ELISAMA S.; ESPINDOLA, ARIANE; BRITOS, TATIANE N.; CHAGAS, CAMILA; BARBOSA, EMERSON; CASTRO, CARLOS E.; FONSECA, FERNANDO L. A.; HADDAD, PAULA S.. Potential Use of DMSA-Containing Iron Oxide Nanoparticles as Magnetic Vehicles against the COVID-19 Disease. CHEMISTRYSELECT, v. 6, n. 31, p. 7931-7935, AUG 20 2021. (18/12219-0, 17/15061-6, 19/07454-3)

DE ESPINDOLA, ARIANE; CHAGAS, CAMILA S.; BARBOSA, EMERSON; CASTRO, CARLOS E.; FONSECA, FERNANDO L. A.; HADDAD, PAULA S.; MOLINA, CELSO. Luminescent - Superparamagnetic iron oxide nanoparticles functionalized with biomolecules and lanthanides ions. Potential platforms for theranostic applications. Journal of Magnetism and Magnetic Materials, v. 545, MAR 1 2022. (12/02708-8, 18/12219-0, 17/15061-6)

CAMPOS, ISABELLE; ESPINDOLA, ARIANE; CHAGAS, CAMILA; BARBOSA, EMERSON; CASTRO, CARLOS E.; MOLINA, CELSO; FONSECA, FERNANDO L. A.; HADDAD, PAULA S.. Biocompatible superparamagnetic nanoparticles with ibuprofen as potential drug carriers. SN APPLIED SCIENCES, v. 2, n. 3, MAR 2020. (18/12219-0, 17/15061-6, 16/22478-8)