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Preventive effect of rice bran on brain inflammatory markers in animals submitted to the consumption of a high-sugar, high-fat diet

Grant number: 19/04280-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2019
Effective date (End): December 31, 2020
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal Investigator:Camila Renata Corrêa
Grantee:Juliana Silva Siqueira
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Obesity is the fifth largest human death cause in the world. The high consume of high-carbohydrates high-fat foods results in inflammatory process, which can affect the functioning of organs such as the brain, resulting in neurodegenerative diseases such as Parkinson's and Alzheimer's. With the purpose of preventing associated with organ inflammation, the change of habits, along with the addition of bioactive such as gamma-oryzanol, which has anti-inflammatory properties, have been subject of research. Wistar Rats (n=40) will be divided randomly in four groups with control diet (C, n=10 animals), control diet + rice bran (C + RB, n=10 animals), high-sugar, high-fat diet (HSF, n=10 animals) and high-sugar, high-fat diet + rice bran (HSF + RB, n=10 animals) for 20 weeks ad libitum. HSF groups will also receive sucrose with 30% concentration in their water with pre-established dietary model. The diet's consume will be controlled daily in order to evaluate the animal's development according to the product's consume and the energy content of the diets. Animal's evaluation include the index of adiposity, systolic blood pressure, glycemic and lipidic plasmatic profile and inflammatory brain markers.