Addition of non-steroidal anti-inflammatory drugs in broiler's diet as alternative to antimicrobial growth promoters

• Grant number: 19/07151-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2019
• End date: April 30, 2023
• Field of knowledge: Agronomical Sciences - Veterinary Medicine
• Principal Investigator: Silvana Lima Gorniak
• Grantee: Mayra Carraro Di Gregorio
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Increasing in frequency of antimicrobial (AM) resistant microorganisms is a subject is a major worldwide concern. One factor that contributes to selection of resistant bacteria is the unrestricted use of AMs. In addition, the widespread use of AMs as a growth performance promoters (AGPs) in animal production may also contribute to bacterial resistance. Several compounds are being evaluated as potential substitutes for AGPs. However, until now, no substance has been able to equate the animal performance gains from AGPs. The most accepted theory about the mechanism of action of AGPs is related to an anti-inflammatory action produced by AMs in low concentrations. Thus, the use of non-steroidal anti-inflammatory drugs (NSAIDs) administered to the broiler ration may promote a performance-enhancing effect. In this way, the present study aims to evaluate the use of oral NSAIDs in broilers, as a growth performance promoters and potential substitute for AMs. Additionally, the effect of the association of NSAIDs with probiotics will also be evaluated. For this, 4 experiments will be performed: 1) evaluation of the efficacy and toxicity of three potential NSAIDs (acetylsalicylic acid, ibuprofen and meloxicam) in three different concentrations incorporated into the broiler diet; 2) Pharmacotechnical study of NSAID that presented the best results; 3) study of the pharmacokinetics of the selected NSAID; 4) evaluation of the effect of two commercial probiotics associated with NSAIDs on broiler performance. Therefore, the project will provide new data on the use of NSAIDs as performance enhancers, as well as on the effects of their association with probiotics in broiler chickens.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DI GREGORIO, MAYRA CARRARO; DE ALMEIDA, ELAINE RENATA MOTTA; MOMO, CLAUDIA; ARAUJO, CRISTIANE SOARES DA SILVA; HUEZA, ISIS MACHADO; ANDREO-FILHO, NEWTON; RASPANTINI, LEONILA ESTER REINERT; GOTARDO, ANDRE TADEU; GORNIAK, SILVANA LIMA. Sodium Salicylate as Feed Additive in Broilers: Absence of Toxicopathological Findings. ANIMALS, v. 13, n. 9, p. 13-pg., 2023-04-22. (19/07151-0, 18/19474-6)