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Fabrication of Biosensors Based on Organic FET and Architected via Organic Electronics and Electrochemistry

Grant number: 18/24395-8
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2019
Effective date (End): January 19, 2021
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal Investigator:Paulo Roberto Bueno
Grantee:Hugo José Nogueira Pedroza Dias Mello
Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated research grant:17/24839-0 - Nanoelectronics and nanoscale electrochemistry: fundaments and applications, AP.TEM


Modern biosensors can perform safe and accurate measurements for diseases that require early diagnosis and emerging diseases, and this is an important paradigm when dealing with such devices. Its fabrication uses advanced scientific and technological principles and concepts, such as organic nanoelectronics and electrochemistry, making use of organic semiconductors as conductive polymers capable of generating flexible, cost-effective, biocompatible, low-cost and higher-response devices. In this project, we intend to fabricate biosensors for such problems, based on solid state devices, more precisely, electrolyte gated organic field effect transistors and electrochemical devices based on impedimetric methods, which gives rise to electrochemical quantum transistors. Both devices use polymeric thin films with chemically active components in their side chains capable of being functionalized by the bio-recognition agents specific to each problem studied. These bio-receptors, which may be enzymes, living cells, DNA strands, antibodies, among others, guarantee the high selectivity of the biosensors through specific chemical reactions with the target analytes. For the development of specific biosensors, such as biosensors applicable to the early diagnosis, specifically, for tumour diseases, DNA strands will be immobilized on the polymer film containing side chains conducive to such a process. The same will refer to the development of a biosensor applicable to emerging diseases, such as Zika or dengue, by immobilizing specific antibodies in the polymer film. The fabricated devices are applied as mesoscopic electrochemical transistors by electrochemical capacitance and field-effect transistors.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MADEIRA, GUSTAVO DANIEL M.; DIAS MELLO, HUGO JOSE N. P.; FALEIROS, MURILO C.; MULATO, MARCELO. Model improvement for super-Nernstian pH sensors: the effect of surface hydration. Journal of Materials Science, v. 56, n. 3, p. 2738-2747, . (18/24395-8, 14/24559-0, 18/22223-5, 17/24201-6)
MELLO, HUGO JOSE NOGUEIRA PEDROZA DIAS; MULATO, MARCELO. Impedimetric and Capacitive Transducer Platform for Chemical Sensors Based on Electrodeposited Polyaniline Thin Films. Journal of Physical Chemistry C, v. 126, n. 29, p. 8-pg., . (17/24839-0, 14/24559-0, 18/24395-8)
PEDROZA DIAS MELLO, HUGO JOSE NOGUEIRA; BUENO, PAULO ROBERTO; MULATO, MARCELO. Comparing glucose and urea enzymatic electrochemical and optical biosensors based on polyaniline thin films. ANALYTICAL METHODS, v. 12, n. 34, p. 12-pg., . (18/24395-8, 17/24839-0)

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