Immunometabolism as new approach to development of "natural adjuvants" that induce regulatory responses

• Grant number: 19/13598-8
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: December 01, 2019
• End date: November 30, 2020
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Dulcineia Saes Parra Abdalla
• Grantee: Gustavo Luis Tripodi
• Supervisor: Daniel Francisco Jacon Ketelhuth
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: Karolinska Institutet, Sweden
• Associated to the scholarship: 17/06568-0 - Immunization of LDLr - / - mice with electronegative LDL mimetic peptides: a potential therapeutic strategy for atherosclerosis, BP.DR

Abstract

The tryptophan metabolism through the kynurenine pathway is pivotal to the polarization of regulatory T cell. Not only tryptophan but also other metabolic pathways such as glycolysis have been shown to modulate immune cell responses. It is our aim to investigate whether tryptophan modulation and the energy metabolism on immune cells can act as "natural adjuvants" and improve anti-atherosclerotic responses induced by experimental vaccines using LDL- mimotopes in vitro.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ARORA, AASTHA; TRIPODI, GUSTAVO LUIS; KAREINEN, ILONA; BERG, MARTIN; FORTEZA, MARIA JOSEFA; GISTERA, ANTON; GRIEPKE, SILKE; CASAGRANDE, FELIPE BECCARIA; MARTINS, JOILSON O.; ABDALLA, DULCINEIA SAES PARRA; et al. Genetic Deficiency of Indoleamine 2,3-dioxygenase Aggravates Vascular but Not Liver Disease in a Nonalcoholic Steatohepatitis and Atherosclerosis Comorbidity Model. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 9, p. 17-pg., 2022-05-01. (19/13598-8, 20/03175-0)