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The role of the anti-ZIKV antibodies in the modulation of the intra-host genetic variability of DENV-2

Grant number: 19/21711-9
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2020
Effective date (End): December 31, 2022
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal researcher:Maurício Lacerda Nogueira
Grantee:Beatriz de Carvalho Marques
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil

Abstract

The World Health Organization (WHO) estimates that vector-borne diseases constitute more than 17% of all the human infectious diseases, causing 700,000 deaths per year. Among these diseases, arboviruses are viral infections transmitted by arthropod vectors in cycles between involving the virus, an invertebrate and a vertebrate hosts. Dengue virus is an acute systemic arbovirus that causes about 390 million infections annually. The Zika virus is another arbovirus responsible for raising a major concern for global public health. The intra-host genetic variation of the arboviruses is not yet clear, and it is necessary to understand the evolutionary events that shape viral populations and the existing population dynamics for their transmission between individuals. Thus, the main objective of this project is to evaluate the intra-host genetic variability of the Dengue virus serotype 2 in patients with acute disease and Zika virus positive serology. The discovery of these processes will help to understand how viruses generate new antigenic variants, develop new routes of transmission, and emerge into new hosts, as well as to understand the immune evasion, providing new perspectives in assessing infection, disease pathogenesis, vaccine, or therapeutic efficacy in patients with Dengue or other related viral infections like Zika. The execution and conclusions of this project will allow publications of worldwide interest, and the experimental techniques to be performed, added to the various scientific collaborations that the project allows, corroborate with the feasibility and multidisciplinary of the doctorate projects. (AU)

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