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Color stability and microhardness of dental enamel irradiated and treated with Higth fluoride toothpastes

Grant number: 19/13910-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2020
Effective date (End): February 28, 2021
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal researcher:Alexandra Mussolino de Queiroz
Grantee:Giulia Battistini Conti
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Radiotherapy is a treatment modality widely used in cases of head and neck cancer, however it can trigger adverse effects such as trismus, decreased salivary flow, oral mucositis, alterations in the palate, orofacial and muscular pain. In mineralized tissues it can cause osteorradionecrosis and dental alterations such as increased instability of the dentin junction, increased collagen degradation and decreased dentin microhardness. There is still no specific literature in the literature evaluating whether radiotherapy for the treatment of head and neck cancer promotes color changes in dental elements or the influence of the use of hyper fluorinated toothpastes under these conditions. Thus, the objective of this study will be to evaluate the possible alteration of tooth color after the irradiation process, simulating a radiotherapy treatment for head and neck cancer, as well as to evaluate the microhardness of the teeth under the action of the simulated brushing with hyperfluorised toothpaste. Thirty bovine teeth will be used, which will be divided into 2 groups. In each one there will be a previous reading of the color of the teeth and initial microhardness evaluation, followed by radiotherapy simulating a treatment for head and neck cancer, a new color and microhardness reading, and then will be submitted to the brushing simulation process for 5 years with the two types of dentifrices, and the final color evaluation and final microhardness of the teeth.

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