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Systems biology applied to transcriptomic analysis of inflammatory diseases

Grant number: 19/22579-7
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Start date: January 01, 2020
End date: December 31, 2021
Field of knowledge:Biological Sciences - Immunology - Immunogenetics
Principal Investigator:Helder Takashi Imoto Nakaya
Grantee:Antonio Edson Rocha Oliveira
Host Institution: Centro de Inovação da USP (INOVA). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/08216-2 - CRID - Center for Research in Inflammatory Diseases, AP.CEPID

Abstract

Inflammatory diseases (e.g. infectious, autoimmune and related to the cardiovascular system) constitute a complex and heterogeneous group of diseases that include a wide range of disorders and conditions characterized by inflammation. Currently, the treatments available for these diseases are limited and sometimes ineffective, requiring a deep understanding of the mechanisms involved in the diseases and the identification of new therapeutic targets for their treatment. Systems biology, which covers the study of interactions and behavior between biological components, including molecules, cells, organs and organisms, appears as a possible solution to this problem. Applying system biology to the study of inflammatory diseases allows us to discover new disease biomarkers, separate patients based on their unique genetic profiles, and direct them to the use of drugs and treatments more effectively. To this end, the use of advanced techniques covering the transcriptome analysis of patients with different inflammatory diseases may provide testable hypotheses and discover new biological targets for the treatment of these diseases. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, VIVIANE CORREA; OLIVEIRA, ANTONIO EDSON ROCHA; CAMPOS, AUGUSTO CESAR BROILO; REIS-CUNHA, JOAO LUIS; BARTHOLOMEU, DANIELLA CASTANHEIRA; TEIXEIRA, SANTUZA MARIA RIBEIRO; LIMA, ANA PAULA C. A.; FERREIRA, RAFAELA SALGADO. The gene repertoire of the main cysteine protease of Trypanosoma cruzi, cruzipain, reveals four sub-types with distinct active sites. SCIENTIFIC REPORTS, v. 11, n. 1, . (13/08216-2, 19/22579-7)
GERMANO, THAIS ANDRADE; RAMOS DE OLIVEIRA, MATHEUS FINGER; AZIZ, SHAHID; ROCHA OLIVEIRA, ANTONIO EDSON; DA CRUZ SARAIVA, KATIA DANIELLA; DOS SANTOS, CLESIVAN PEREIRA; HERBSTER MOURA, CARLOS FARLEY; COSTA, JOSE HELIO. Transcriptome profiling of cashew apples (Anacardium occidentale) genotypes reveals specific genes linked to firmness and color during pseudofruit development. Plant Molecular Biology, v. 109, n. 1-2, p. 18-pg., . (13/08216-2, 19/22579-7)
DA SILVA, JOSIANE FERNANDES; BOLSONI, JULIANA A.; DA COSTA, RAFAEL M.; ALVES, JULIANO, V; BRESSAN, ALECSANDER F. M.; SILVA, LUIZ EDUARDO, V; COSTA, TIAGO J.; OLIVEIRA, ANTONIO E. R.; MANZATO, CARLA P.; AGUIAR, CARLOS A.; et al. Aryl hydrocarbon receptor (AhR) activation contributes to high-fat diet-induced vascular dysfunction. British Journal of Pharmacology, v. 179, n. 12, p. 15-pg., . (18/21199-3, 13/08216-2, 19/22579-7, 16/16207-1)