Investigation of molecular bases of multifactorial chronic diseases in the population of São Paulo by GWAS

• Grant number: 19/23985-9
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: March 01, 2020
• End date: January 31, 2024
• Field of knowledge: Health Sciences - Nutrition
• Principal Investigator: Regina Mara Fisberg
• Grantee: Jaqueline Lopes Pereira França
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 17/05125-7 - Lifestyle, biochemical and genetic markers as cardiometabolic risk factors: Health Survey in São Paulo City, AP.TEM

Abstract

The purpose of this project is to conduct Genome-Wide Association Study (GWAS) to identify genetic factors associated with susceptibility to chronic noncommunicable diseases such as Obesity, Diabetes, Hypertension, Dyslipidemia, and Osteoporosis. For this, 800.000 genetic markers (Single Nucleotide Polymorphisms - SNP) will be genotyped in 864 individuals. Statistical analyzes will be performed in R statistical software, with packages such as Bioconductor and SNPassoc, which allow case and control studies considering the phenotypes as discontinuous (dichotomous; having or not the disease) and phenotype analysis as variables (values of blood pressure, anthropometric parameters, bone mineral density and biochemical measurements of blood tests). (AU)