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Investigation of molecular bases of multifactorial chronic diseases in the population of São Paulo by GWAS

Grant number: 19/23985-9
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2020
Effective date (End): February 28, 2022
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Regina Mara Fisberg
Grantee:Jaqueline Lopes Pereira França
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:17/05125-7 - Lifestyle, biochemical and genetic markers as cardiometabolic risk factors: Health Survey in São Paulo City, AP.TEM

Abstract

The purpose of this project is to conduct Genome-Wide Association Study (GWAS) to identify genetic factors associated with susceptibility to chronic noncommunicable diseases such as Obesity, Diabetes, Hypertension, Dyslipidemia, and Osteoporosis. For this, 800.000 genetic markers (Single Nucleotide Polymorphisms - SNP) will be genotyped in 864 individuals. Statistical analyzes will be performed in R statistical software, with packages such as Bioconductor and SNPassoc, which allow case and control studies considering the phenotypes as discontinuous (dichotomous; having or not the disease) and phenotype analysis as variables (values of blood pressure, anthropometric parameters, bone mineral density and biochemical measurements of blood tests). (AU)