KIR3DL2 3'UTR diversity in Brazilian samples and microRNA binding profile

• Grant number: 19/27258-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2020
• End date: December 31, 2020
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: Erick da Cruz Castelli
• Grantee: Arielle Lima da Rocha
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The Killer cell immunoglobulin-like receptors (KIR) complex encode many surface receptors that are expressed in Natural Killer (NK) cells. Their main ligands are the highly variable HLA class I molecules. KIR receptors modulate NK activity positively or negatively, depending on the receptor and the ligands. Here we will evaluate the KIR3DL2 3'UTR diversity in highly admixed Brazilian samples and define the most common 3'UTR haplotypes. Then, we will search for microRNAs that may modulate KIR3DL2 expression, especially does binding to polymorphic segments. (AU)