Risk factors for the evolution of renal outcomes in Autosomal Dominant Polycystic Kidney Disease

• Grant number: 19/22862-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2020
• End date: March 31, 2021
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Luis Cuadrado Martin
• Grantee: Andrey Gonçalves Santos
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary disorder characterized by the formation of cysts in the renal parenchyma. Cystic expansion leads to compression of adjacent nephrons, as well as an inflammatory process that results in progression to renal fibrosis, with increasing loss of nephrons, culminating in decreased renal function and leading patients to dialysis. Identifying risk factors associated with the development of ADPKD is essential for clinical practice, allowing patients to be treated more incisively in order to reduce the morbidity and mortality of this disease. However, we did not identify papers that have evaluated this subject in Brazilian casuistry. Thus, the purpose of this study is to analyze the risk factors for the evolution of renal outcomes in ADPKD by means of a longitudinal cohort. ADPKD patients treated at our hospital will be evaluated for the first time between January 2002 and December 2014 and followed until December 2019, seeking associations of clinical and laboratory variables with renal endpoints of creatinine doubling or patient death to patents with glomerular filtration rate between 30 and 60 mL/min. Cox proportional regression will be used and the value of p <0.05 will be considered statistically significant. To patients with Glomerular filtration rate above 60 mL/min, primary outcome will be rate of loss of glomerular filtration rate. (AU)