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Impact of school-based annual HPV vaccination on the vaccine coverage in the city of Indaiatuba (SP)

Grant number: 20/05103-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2020
Effective date (End): April 30, 2021
Field of knowledge:Health Sciences - Collective Health - Preventive Medicine
Principal Investigator:Júlio César Teixeira
Grantee:Daniella Moretti Arbore
Host Institution: Centro de Atenção Integral à Saúde da Mulher (CAISM). Hospital da Mulher Professor Doutor José Aristodemo Pinotti. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Cervical cancer is an important public health problem, standing out as the third most common malignant tumor among women. It is a disease with a causative agent, HPV, whose infection can be prevented. It is known that at least 80% of female adolescent vaccination, before the beginning of the sexual activity, has the potential to reduce this cancer by up to 70%. In Brazil, there are three vaccines registered by the National Health Vigilance Agency and two are available for use. The Brazilian Unified Health System offers the quadrivalent vaccine, against HPV-16/18/6/11, in the National Immunization Program since 2014, however, vaccination coverage is very low in target populations up to 14 years of age. This low vaccination coverage was accentuated in 2015 after the vaccination was transferred from schools to the Health Basic Units. In the city of Indaiatuba, the same low coverage was verified and trying to modify this scenario, a local survey showed that the municipality had around 83 % of the population between 9 and 10 years of age enrolled in the municipal network and this led to the establishment of the Municipal Plan for HPV Vaccination (PMV-HPV), started in 2018, which performs HPV vaccination on a school basis for boys and girls from nine and 10 years, with two doses applied annually. This longitudinal study aims to evaluate the results of PMV-HPV in the municipality of Indaiatuba (SP) after two years, with the annual evolution of vaccination coverage against HPV in boys and girls. The information to be analyzed will be obtained directly from the municipal records of the PMV-HPV and, via the web, from the Information System of the National Immunization Program (SI-PNI). A database will be set up, calculating vaccination coverage by age and gender, in the campaign periods (vaccination in schools) and outside (vaccination in UBS), and before and after the implementation of the annual vaccination program, on a school basis, equalizing age regardless of gender, and possible changes in vaccination coverage at other ages. Possible refusals by those responsible for vaccination in schools and the occurrence of recorded adverse events will be investigated. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
JULIO CESAR TEIXEIRA; MARIANA SILVA CASTRO VIANNA; DIAMA BHADRA VALE; DANIELLA MORETTI ARBORE; THAIS HELENA WILMERS PERINI; TULIO JOSE TOMASS COUTO; JOSE PEDROSO NETO; LUIZ CARLOS ZEFERINO. Vacinação contra o HPV em base escolar: Os desafios de uma iniciativa brasileira. Revista Brasileira de Ginecologia e Obstetrícia, v. 43, n. 12, p. 926-931, . (20/05103-6)

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