Social determinants of health in multidrug-resistant tuberculosis patients

• Grant number: 20/02181-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): July 01, 2020
• Effective date (End): June 30, 2021
• Field of knowledge: Health Sciences - Nursing - Public Health Nursing
• Principal Investigator: Pedro Fredemir Palha
• Grantee: Marina Bortoletti Vieira Arantes
• Host Institution: Escola de Enfermagem de Ribeirão Preto (EERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Tuberculosis remains an important public health problem worldwide and is closely related to social determinants of health. Such scenario is even more complex regarding cases of resistance to antimicrobials and multidrug-resistant tuberculosis represents its most severe form. Multidrug-resistant tuberculosis is a serious threat to the lives of the affected people, with high individual and collective consequences, resulting in economic and social costs - having an extensive treatment in Reference Centers, a high incidence of side effects and low success rates. For these reasons, it is extremely necessary to investigate factors that may be related to the success or not of the treatment. Thus, the current study aims to identify the association between social determinants of health and the outcome of treatment for multidrug-resistant tuberculosis in the Reference Center in the interior of the state of São Paulo. This is a retrospective cohort study, carried out with secondary data from all patients who underwent treatment at the service studied between 1996 and 2016. A systematic consultation will be carried out with medical records, characterizing the social determinants, clinical data of previous treatments and current status for multidrug-resistant tuberculosis. The data obtained will be typed into a Microsoft® Excel 2013 spreadsheet and the analysis will be performed using software R version 3.6.0. Three outcome comparison models will be built: Success versus Abandonment; Success versus Death; and Success versus treatment failure. (AU)