NMR metabolomics: metabolomic profiles of Vero cells infected with Zika and Chikungunya and inhibition by wedelolactone

• Grant number: 20/03639-6
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: September 01, 2020
• End date: January 31, 2024
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Raghuvir Krishnaswamy Arni
• Grantee: Rafaela dos Santos Peinado
• Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil

Abstract

Based on the necessity to better understand the virus-host and inhibitor-virus-host interaction, the present proposal focuses on the identification of the metabolic alterations caused in culture cells by Zika and Chikungunya, both responsible for current arbovirus epidemics for which the available treatments are based on vector control and treatment of symptoms with medication, as well as investigate the action of the wedelolactone molecule on both the infection and on cellular metabolism, as a previously identified inhibitor of viral proteases in two post doctoral projects in our research group to which this project is linked, using Metabolomics by nuclear magnetic ressonance. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEINADO, RAFAELA DOS S.; EBERLE, RAPHAEL J.; ARNI, RAGHUVIR K.; CORONADO, MONIKA A.. A Review of Omics Studies on Arboviruses: Alphavirus, Orthobunyavirus and Phlebovirus. Viruses-Basel, v. 14, n. 10, p. 28-pg., 2022-10-01. (20/08615-8, 20/03639-6)

PEINADO, RAFAELA DOS S.; EBERLE, RAPHAEL J.; PACCA, CAROLINA C.; ARNI, RAGHUVIR K.; CORONADO, MONIKA A.. Review of -omics studies on mosquito-borne viruses of the Flavivirus genus. VIRUS RESEARCH, v. 307, p. 18-pg., 2022-01-02. (20/03639-6)