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Evaluation of superficial lymph nodes in dogs diagnosed with visceral leishmaniasis

Grant number: 20/06379-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2020
Effective date (End): July 31, 2021
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
Principal researcher:Elisângela Olegário da Silva
Grantee:Tifany da Silva Sato Roca
Home Institution: Faculdade de Ciências Agrárias. Universidade do Oeste Paulista (UNOESTE). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

Visceral leishmaniasis (VL) is a disease with high mortality, neglected, with worldwide distribution, mainly in South America, with greater notification in Brazil. The domestic dog is the main reservoir of VL in endemic regions and plays a fundamental role in the maintenance and expansion of this disease. Therefore, knowledge of the pathogenesis, immune response, and clinical manifestations are essential for the establishment of preventive and control measures for canine visceral leishmaniasis (CVL). The West Paulista region has an increasing number of dogs diagnosed with CVL, however, there are no studies with this population of animals. This project aims to evaluate the superficial lymph nodes of dogs diagnosed with VL by the cytopathological and histopathological exams and determine the parasitic density, immune response, and morphological changes, correlating the results with the clinical manifestations of the disease.