Development of a novel bioink for 3D printing scaffolds for regeneration of cartilage tissues

• Grant number: 20/04009-6
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: October 01, 2020
• End date: January 31, 2025
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Antonio Claudio Tedesco
• Grantee: Henrique Luis Piva
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated scholarship(s): 21/11803-3 - Design and production of bone vascular scaffolds, BE.EP.DD

Abstract

Cartilage injuries rarely heal and often lead to degenerative changes in joints. Some therapies, such as autologous chondrocyte transplantation, have some efficacy in the generation of new tissues, however, the surgical procedure requires two surgeries in the same region, and the obstacles to the delivery of live cells prevent the widespread use. In addition, clinical studies comparing chondrocyte transplantation with simple surgical strategies have found no significant improvement in clinical outcomes.The research line proposed for this project aims at combining Tissue Engineering processes, 3D printing associated with cell cultures, aiming at the production of scaffolds for regeneration of cartilaginous ligaments and structures, in a micro-perfusable 3D model suitable for culture long-term ex-vivo and possible implantation. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARBOSA, HELLEN FRANCIANE GONCALVES; PIVA, HENRIQUE LUIS; MATSUO, FLAVIA SAYURI; DE LIMA, SARAH CAROLINE GOMES; DE SOUZA, LUCAS EDUARDO BOTELHO; OSAKO, MARIANA KIOMY; TEDESCO, ANTONIO CLAUDIO. Hybrid lipid-biopolymer nanocarrier as a strategy for GBM photodynamic therapy (PDT). International Journal of Biological Macromolecules, v. 242, p. 14-pg., 2023-05-08. (18/17911-0, 13/50181-1, 20/04009-6)

CABRAL, AGATA SILVA; RIVAS LEONEL, ELLEN CRISTINA; CANDIDO, NATALIA MARIA; PIVA, HENRIQUE LUIS; DE MELO, MARYANNE TRAFANI; TABOGA, SEBASTIAO ROBERTO; RAHAL, PAULA; TEDESCO, ANTONIO CLAUDIO; CALMON, MARILIA FREITAS. Combined photodynamic therapy with chloroaluminum phthalocyanine and doxorubicin nanoemulsions in breast cancer model. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 218, MAY 2021. (20/04009-6, 13/50181-1)

GOBO, GRACIELY GOMIDES; PIVA, HENRIQUE LUIS; TEDESCO, ANTONIO CLAUDIO; PRIMO, FERNANDO LUCAS. Novel quinizarin spray-dried nanoparticles for treating melanoma with photodynamic therapy. MATERIALS TODAY COMMUNICATIONS, v. 33, p. 9-pg., 2022-11-11. (13/50181-1, 20/04009-6)

DOS SANTOS, LUIZ FERNANDO; GOMES, LUIZ FERNANDO TOMAZINI; LIMA, KARMEL DE OLIVEIRA; DALOSSIO, VINICIUS PAULINO; CALORI, ITALO RODRIGO; BORGES, HIAGO SALGE; PIVA, HENRIQUE LUIS; TEDESCO, ANTONIO CLAUDIO; GOLDNER, PHILIPPE; GONCALVES, ROGERIA ROCHA. Upconversion luminescent hollow Er3+,Yb3+ co-doped Y2SiO5 spheres for biophotonics: In vitro cytotoxicity and cellular sub-locality evaluation in glioblastoma cells. MATERIALS TODAY COMMUNICATIONS, v. 42, p. 11-pg., 2025-01-01. (20/04009-6, 20/04157-5, 21/08111-2, 21/11803-3, 23/03092-5, 18/18213-4, 20/05319-9)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PIVA, Henrique Luis. Three-dimensional scaffolds for tissue regeneration. 2025. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (PCARP/BC) Ribeirão Preto.