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Redox balance in cardiorenal Syndrome: emphasis on vascular purinergic receptors

Grant number: 20/07816-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2020
Effective date (End): November 30, 2021
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Cristina Ribas Fürstenau
Grantee:Geovane Felippe Alves
Home Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil

Abstract

Cardiorenal syndrome (SCR) is characterized as a set of cardiac and renal dysfunctions, in which the injury of one organ generates disturbances in the other, Besides, SCR causes a perceptible oxidative imbalance in the plasma due to the fine interaction and relationship between the two systems. The vascular system, responsible for transporting blood throughout the body, is also affected by SCR, through neurohumoral, hemodynamic, biochemical, and oxidative stress factors. The purinergic system is a cell signaling system performed by nucleotides and nucleosides with prominence in vascular function since it mediates vasodilation and vasoconstriction. Also, purinergic system is considered an important anti-apoptotic system when there is a redox imbalance. Thus, the objective of this project is to analyze the possible alteration in the gene expression of purinergic receptors in the vasculature in response to oxidative stress originating from SCR.