Advanced search
Start date
Betweenand

Sonothrombolysis: delving into the physical foundations of the clinical application

Grant number: 20/10819-0
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): September 01, 2020
Effective date (End): August 31, 2023
Field of knowledge:Engineering - Biomedical Engineering
Principal researcher:Sergio Shiguemi Furuie
Grantee:Vitor Gabriel Barra Souza
Home Institution: Escola Politécnica (EP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:18/06387-8 - High ultrasound mechanical index and microbubbles to reduce acute myocardial infarction burden I. HUBBLE-I study, AP.TEM

Abstract

Sonothrombolysis (ultrasound-mediated thrombolysis) is an emerging treatment for acute myocardial infarction based on inducing the cavitation of gas bubbles near culprit thrombi, i.e. causing the bubbles to oscillate in volume until they collapse violently and rupture, at which point their surroundings may experience significant mechanical damage. This damage has been shown to assist the degradation of thrombi, but it may also exert unintended effects on healthy tissues. This research project seeks to perform a multi-objective optimization of the specifications of an ideal sonothrombolysis system, such that (i) it is effective in degrading thrombi while; (ii) retaining an acceptable safety profile. This task is highly complicated since no satisfactory mathematical model exists for sonothrombolysis, therefore requiring a low-level modeling of elementary physical phenomena together with extensive numerical and physical experiments. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)