Development of customized mandible prosthesis produced by additive manufacturing and functionalized for local drug delivery

• Grant number: 20/05612-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: November 01, 2020
• End date: January 31, 2024
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Rubens Maciel Filho
• Grantee: Guilherme Arthur Longhitano
• Host Institution: Faculdade de Engenharia Química (FEQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 15/20630-4 - Biorefinery development integrated to a bioethanol sugar cane plant with zero CO2 emission: routes to convert renewable resources to bio-products and bio-electricity, AP.TEM
• Associated scholarship(s): 21/06516-5 - Surface functionalization and characterization of porous Ti-6Al-4V alloy made by additive manufacturing for mandible prosthesis, BE.EP.PD

Abstract

The additive manufacturing technique, when based on medical imaging techniques, can produce physical biomodels and customized implants. The technique can also produce complex structures, such as cellular structures, using metallic biomaterials, such as a Ti-6Al-4V alloy, as raw material. Therefore, better conformity of bone and implant stiffness is achieved, bypassing the bone resorption (stress shielding) process and promoting faster and longer lasting adaptation. The Ti-6Al-4V alloy may also have its surface modified by the anodizing technique. As a result, functionalizations by improving corrosion resistance, incorporation of beneficial ions and drug incorporation for in situ delivery become possible. The combination of these techniques results in reduced surgery risks, faster patient recovery, longer implant durability, better aesthetic and ergonomic results and, above all, improvement in patient's quality of life.This project aims to produce a Ti-6Al-4V mandible implant with functionalized cellular structure. Thus, Ti-6Al-4V samples with cellular structures will be produced by metals additive manufacturing technique. These samples will be functionalized by electrochemical anodization technique, growing nanostructured oxide surfaces doped with fluorine ions. A second functionalization will also be performed by doping these nanostructures with drugs for in situ delivering. Finally, a mandible implant will be designed, produced and functionalized.This project is linked to National Institute of Science and Technology of Biofabrication presented under the INCT - MCTI/CNPq/CAPES/FAPs nº 16/2014 call, to FAPESP research project 2015/20630-4 and to FAPESP-FAPERGS 2019/15441-9. Furthermore, this project is in collaboration with Information Technology Center Renato Archer. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

IATECOLA, AMILTON; LONGHITANO, GUILHERME ARTHUR; MARTINEZ ANTUNES, LUIZ HENRIQUE; JARDINI, ANDRE LUIZ; MIGUEL, EMILIO DE CASTRO; BERES, MILOSLAV; LAMBERT, CARLOS SALLES; ANDRADE, TIAGO NEVES; BUCHAIM, ROGERIO LEONE; BUCHAIM, DANIELA VIEIRA; et al. Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing. PHARMACEUTICS, v. 13, n. 5, MAY 2021. (20/05612-8)

SANTOS, PEDRO BELL; DE CASTRO, VICTOR VELHO; BALDIN, ESTELA KERSTNER; AGUZZOLI, CESAR; LONGHITANO, GUILHERME ARTHUR; JARDINI, ANDRE LUIZ; NAJAR LOPES, EDER SOCRATES; HELGUEIRA DE ANDRADE, ANTONIO MARCOS; MALFATTI, CELIA DE FRAGA. Wear Resistance of Plasma Electrolytic Oxidation Coatings on Ti-6Al-4V Eli Alloy Processed by Additive Manufacturing. METALS, v. 12, n. 7, p. 15-pg., 2022-07-01. (19/15441-9, 20/05612-8)

LONGHITANO, GUILHERME ARTHUR; CONDE, ANA; ARENAS, MARIA ANGELES; JARDINI, ANDRE LUIZ; DE CARVALHO ZAVAGLIA, CECILIA AMELIA; MACIEL FILHO, RUBENS; JOSE DE DAMBORENEA, JUAN. Corrosion resistance improvement of additive manufactured scaffolds by anodizing. Electrochimica Acta, v. 366, JAN 10 2021. (19/15441-9, 20/05612-8)

LONGHITANO, GUILHERME ARTHUR; RIBEIRO MACHADO, LEONARDO MENDES; JARDINI, ANDRE LUIZ; BALDIN, ESTELA KERSTNER; SANTOS, PEDRO BELL; MACIEL FILHO, RUBENS; MALFATTI, CELIA DE FRAGA; DE CARVALHO ZAVAGLIA, CECILIA AMELIA. Fracture behavior under compression loading of surface-cleaned metallic lattice structures. INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY, v. N/A, p. 13-pg., 2022-06-20. (19/15441-9, 20/05612-8)

BALDIN, ESTELA KERSTNER; DE CASTRO, VICTOR VELHO; SANTOS, PEDRO BELL; AGUZZOLI, CESAR; BERNARDI, FABIANO; MEDEIROS, THALLYSON; MAURMANN, NATASHA; PRANKE, PATRICIA; FRASSINI, RAFAELE; ROESH, MARIANA ELY; et al. Copper incorporation by low-energy ion implantation in PEO-coated additively manufactured Ti6Al4V ELI: Surface microstructure, cytotoxicity and antibacterial behavior. Journal of Alloys and Compounds, v. 940, p. 11-pg., 2023-04-15. (19/15441-9, 20/05612-8)