Synthesis of new enantioenriched half-sandwich ligands and its applications to enantioselective ruthenium-catalyzed C-H functionalization reactions

• Grant number: 20/12435-5
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: November 01, 2020
• End date: October 31, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Caio Costa Oliveira
• Grantee: Erick Martins de Carvalho Pinheiro
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 18/01669-5 - New quiral metal catalysts and their applications in asymmetric catalysis, AP.JP

Abstract

The functionalization organic molecules through the activation of C-H bonds are among the most common transition metals catalyzed reactions. Despite the large number of examples in enantioselective transformations, there are still no reports on the use of ruthenium as a catalyst. This project aims to develop the first C-H activation reaction for this metal, using new half-sandwich ligands as the source of chirality. (AU)