Native american genomic variability and its possible influence on the response to pathogens

• Grant number: 20/10136-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: November 01, 2020
• End date: September 30, 2022
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: Tábita Hünemeier
• Grantee: Renan Barbosa Lemes
• Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 20/05326-5 - Genomic and epidemiological aspects of the COVID-19 in native Brazilian populations, AP.R

Abstract

The present project aims at sequencing 40 complete genomes of individuals infected with SARS-CoV-2 from two Native American populations in Espírito Santo (Brazil) in order to unveil their genomic variability and its possible relationship with the clinical outcomes presented. The specific objectives of the project are: a. Elucidate native American native variability and its relationship to the spread and evolution of COVID-19. B. Establish the genetic susceptibility of these individuals to SARS-CoV-2 infection, and their dependence on pre-existing clinical factors (i.e. diabetes, tuberculosis). c. In silico modeling of the protein changes resulting from mutations in regions encoding genes already related to the evolution of COVID-19 (i.e. ACE2, IL-6, TMPRSS2), as well as highly differentiated genomic regions in individuals with different clinical outcomes. d. To verify the impact of the mutations found in the native population in the admixed individuals of the DNA do Brazil project (1000 Brazilians already sequenced), who present different degrees of miscegenation with Native Americans.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CASTRO E SILVA, MARCOS ARAUJO; FERRAZ, TIAGO; COUTO-SILVA, CAINA M.; LEMES, RENAN B.; NUNES, KELLY; COMAS, DAVID; HUNEMEIER, TABITA. Population Histories and Genomic Diversity of South American Natives. Molecular Biology and Evolution, v. 39, n. 1, p. 17-pg., 2021-12-21. (15/26875-9, 20/10136-0, 17/14916-8, 16/12371-1)