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Clinical evaluation of the biocompatibility of polyvinylidene fluoride, nylon and polyglactin 910 lines implanted in the muscle of horses

Grant number: 20/10480-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2020
Effective date (End): November 30, 2021
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal researcher:Marcos Jun Watanabe
Grantee:Isabella Gonçalves Netto Alt dos Reis
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The occurrence of incisional complications after ventral median celiotomy in horses is described from 16.8% to 80%, the most common being edema, exudation, infection, hernia formation and dehiscence of the suture, and these can lead to discomfort abdominal, delayed recovery, increased costs of treatment and numbers of days hospitalized. The factors that predispose complications are classified between systemic and local, these are trauma to the wound margins, large amount of fatty tissue, time prolonged surgery, difficulty in anesthetic recovery, excessive physical activity and inadequate choice of material for tissue synthesis.Whereas studies have already evaluated the characteristics of the polyglactin 910 and nylon lines in horses, the present research has the object to compare clinical characteristics, ultrasonography, thermographic and algometric of the implanted regions with polyvinylidene fluoride (PVDF), polyglactin 910 and nylon lines, implanted in the skeletal muscles of horses. Six horses, gelding and healthy will be submitted to the implantation of suture line in the skeletal musculature of the right and left cervical sides, the groups will be formed according to the material composition of the suture lines: Polyvinylidene fluoride group (PVDF); Nylon group (NG) and Polyglactin 910 group (GP). To implantation of the lines will be performed with the horses under sedation, local anesthesia, and preparation surgical. During the first 7 days, the horses will be monitored by physical examination, thermographic and algometric every 24h and ultrasonographic every 48 h. After this time, the regions will be monitored in the 14th and 28th days after of the implantation. Thermographic and algometric evaluations will be performed according to the method described in the literature and ultrasonography to the presence of edema and echogenicity characteristics.