Biomechanical and histological evaluation of implants with hydrophilic surface in systemic disease

• Grant number: 20/11342-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2021
• End date: December 31, 2022
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Rosemary Adriana Chierici Marcantonio
• Grantee: Gabriel Gimenez Pedroso
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The aim is to evaluate the effect of systemic condition (obesity and use of bisphosphonate) on the osseointegration of implants with hydrophilic surface. 96 rats will be used and these animals will be allocated into 3 groups with 16 animals each: Hydrophilic group (GH): implant with hydrophilic surface, Hydrophilic/Obese group (GH-O): implant with hydrophilic surface and obese animals; Hydrophilic/Bisphosphonate group (GH-B): implant with hydrophilic surface and animals that use bisphosphonate, Hydrophobic group (GH): implant with hydrophobic modified surface, Hydrophobic/Obese group (GH-O): implant with hydrophobic modified surface and obese animals; Hydrophobic/Bisphosphonate group (GH-B): implant with hydrophobic modified surface and animals that use bisphosphonate.. The implants will be installed in the animals' tibia and after 15 and 45 days the animals will be euthanized. The osseointegration process will be evaluated by biomechanical tests (torque removal) and histological analyses (quality of the bone, formation of vessels, quality of the connective tissue matrix and appearance of the cells that make up the bone tissue).