The influence of the CYP1A2 polymorphism on the physiological responses and performance following acute supplementation with caffeine

• Grant number: 20/12036-3
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: March 01, 2021
• End date: September 09, 2024
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Bryan Saunders
• Grantee: Gabriel Henrique Castanho Barreto
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 16/50438-0 - Nutritional suplementation and exercise to optimize exercise performance: focus on individual responses and a step towards personalized sports nutrition, AP.JP
• Associated scholarship(s): 21/12116-0 - Caffeine, CYP1A2 genotypes and exercise performance: just a matter of timing?, BE.EP.DD

Abstract

Caffeine is the most consumed psychoactive substance in the world. Its properties are valuable in sports, since it acts as an adenosine receptor antagonist, increasing the noradrenaline and dopamine release of the central nervous system, reducing perceived exertion and pain and reducing fatigue. Despite its beneficial effects, some people appear not to benefit from caffeine supplementation, with purported genetic differences considered a contributing factor. It has been hypothesized that the CYP1A2 -163C>A polymorphism is the main gene responsible for these differences, considering that the C-allele carriers are slow metabolizers and could benefit less from caffeine intake when compared to homozygous AA for this gene (fast metabolizers). However, the time-course profile of caffeine in blood, and its derivates (dimethylxanthines), and the relation with genotype have not been shown in the literature. Also, the performance differences between individuals with different genotypes are contradictory and use small sample sizes. The aim of this study is to determine whether there are changes in the time-course of blood caffeine and dimethylxanthines concentration and performance between the different genotypes for CYP1A2. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GUARDIEIRO, NATALIA MENDES; BARRETO, GABRIEL; MARTICORENA, FELIPE MIGUEL; OLIVEIRA, TAMIRES NUNES; DE OLIVEIRA, LUANA FARIAS; PINTO, ANA LUCIA DE SA; DO PRADO, DANILO MARCELO LEITE; SAUNDERS, BRYAN; GUALANO, BRUNO. A Cloth Facemask Causes No Major Respiratory or Cardiovascular Perturbations During Moderate to Heavy Exercise. JOURNAL OF PHYSICAL ACTIVITY & HEALTH, v. 20, n. 1, p. 10-pg., 2023-01-01. (21/05847-8, 16/50438-0, 20/12036-3, 17/13552-2, 21/06836-0, 20/04368-6)

MARTICORENA, FELIPE MIGUEL; BARRETO, GABRIEL CASTANHO; GUARDIEIRO, NATALIA MENDES; ESTEVES, GABRIEL PERRI; OLIVEIRA, TAMIRES NUNES; DE OLIVEIRA, LUANA FARIAS; PINTO, ANA LUCIA DE SA; RIANI, LUIZ; PRADO, DANILO MENDES; SAUNDERS, BRYAN; et al. Performing moderate to severe activity is safe and tolerable for healthy youth while wearing a cloth facemask. PLoS One, v. 18, n. 3, p. 11-pg., 2023-03-06. (21/05847-8, 16/50438-0, 20/12036-3, 17/13552-2, 20/07860-9, 20/04368-6)

CARVALHO, ARTHUR; MARTICORENA, FELIPE MIGUEL; GRECCO, BEATRIZ HELENA; BARRETO, GABRIEL; SAUNDERS, BRYAN. Reply to Zhang and Chen's Comment on "Can I Have My Coffee and Drink It? A Systematic Review and Meta-analysis to Determine Whether Habitual Caffeine Consumption Affects the Ergogenic Effect of Caffeine". SPORTS MEDICINE, v. 53, n. 2, p. 2-pg., 2022-10-16. (20/12036-3, 20/02391-0, 21/05847-8, 21/06836-0)

CARVALHO, ARTHUR; MARTICORENA, FELIPE MIGUEL; GRECCO, BEATRIZ HELENA; BARRETO, GABRIEL; SAUNDERS, BRYAN. Can I Have My Coffee and Drink It? A Systematic Review and Meta-analysis to Determine Whether Habitual Caffeine Consumption Affects the Ergogenic Effect of Caffeine. SPORTS MEDICINE, v. N/A, p. 12-pg., 2022-05-10. (20/12036-3, 21/05847-8, 20/02391-0, 16/50438-0, 19/20614-0, 21/06836-0)

MENDES, GUILHERME FALCAO; REIS, CAIO EDUARDO GONCALVES; NAKANO, EDUARDO YOSHIO; SPINELI, HIGOR; BARRETO, GABRIEL; NORONHA, NATALIA YUMI; WATANABE, LIGIA MORIGUCHI; NONINO, CARLA BARBOSA; DE ARAUJO, GUSTAVO GOMES; SAUNDERS, BRYAN; et al. Can the Brazilian Caffeine Expectancy Questionnaires Differentiate the CYP1A2 and ADORA2A Gene Polymorphisms?-An Exploratory Study with Brazilian Athletes. NUTRIENTS, v. 14, n. 16, p. 12-pg., 2022-08-01. (18/24069-3, 20/12036-3, 21/06836-0, 16/50438-0, 20/08687-9)

ANDRE, HELOISA C. SANTO; ESTEVES, GABRIEL P.; BARRETO, GABRIEL. H. C.; LONGHINI, FERNANDO; DOLAN, EIMEAR; BENATTI, FABIANA B.. The Influence of n-3PUFA Supplementation on Muscle Strength, Mass, and Function: A Systematic Review and Meta-Analysis. ADVANCES IN NUTRITION, v. 14, n. 1, p. 13-pg., 2023-02-21. (19/17912-9, 19/05616-6, 20/12036-3, 20/07860-9, 19/26899-6, 20/02741-1, 21/12116-0)