Chemical study of the Caatinga propolis produced by Apis mellifera and re-isolation of red propolis compounds to perform biological tests and develop analytical methods.

• Grant number: 21/01411-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2021
• End date: January 31, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Jairo Kenupp Bastos
• Grantee: Ninh The Son
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector, AP.TEM

Abstract

Brazilian propolis produced by Apis mellifera, popularly known as green, brown, and red, with approximately 200 tons produced per year, is highly economically relevant to Brazil since they are exported to several countries, especially Japan and China. In addition to the well-known propolis, there is propolis that has not yet been studied, as is the case of propolis produced in Northeastern Brazil's "Caatinga vegetation." This propolis has market potential, but studies must be carried out to develop this new Brazilian propolis. Thus, it is proposed to carry out detailed chemical studies of isolation and structural identification of the major and minor metabolites of this unprecedented propolis from the Caatinga and its botanical source. Also, red propolis compounds, whose botanical sources are Dalbergia ecastaphyllumm and Symphonia globulifera, will be re-isolated to be used in the development of analytical methods and conducting biological tests in the ongoing thematic project entitled: "Conducting chemical, analytical, biological, pharmacological and technological studies to fill the gaps in the development of the Brazilian propolis sector." (AU)

Scientific publications

(4)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

SON, NINH THE; RIBEIRO, VICTOR PENA; BASTOS, JAIRO KENUPP. Flavonoids from green propolis of the Northeastern Brazilian Caatinga Mimosa tenuiflora (Willd.) Poir.: A chemotaxonomic aspect. Biochemical Systematics and Ecology, v. 104, p. 4-pg., 2022-08-03. (21/01411-0, 17/04138-8, 17/08386-6)

SON, NINH THE; RIBEIRO, VICTOR PENA; TEIXEIRA, MARIA VALDELINE SOUSA; FURTADO, NIEGE ARACARI JACOMETTI CARDOSO; BASTOS, JAIRO KENUPP. Northeastern Caatinga Green Propolis: Volatile Oil and Antimicrobial Activity. CHEMISTRY OF NATURAL COMPOUNDS, v. N/A, p. 3-pg., 2023-09-15. (21/01411-0, 17/04138-8)

SON, NINH THE; GIANIBBI, BEATRICE; PANTI, ALICE; SPIGA, OTTAVIA; BASTOS, JAIRO KENUPP; FUSI, FABIO. 3,3′-O-dimethylquercetin: A bi-functional vasodilator isolated from green propolis of the Caatinga Mimosa tenuiflora. European Journal of Pharmacology, v. 967, p. 13-pg., 2024-02-17. (21/01411-0, 17/04138-8, 17/08386-6)

LUYEN, NGUYEN DINH; HAO, NGUYEN THANH; BASTOS, JAIRO KENUPP; HA, NGUYEN XUAN; HUNG, NGUYEN HUY; GIOI, DONG HUY; LINH, NGUYEN NGOC; SON, NINH THE. Flavonoids from Mimosa tenuiflora Green Propolis: Chemotaxonomy, Antioxidant, Anti-Inflammation, Anti-Bacteria, Mosquito Larvicidal Activity, and In Silico Approach. CHEMISTRYSELECT, v. 9, n. 23, p. 10-pg., 2024-06-18. (21/01411-0, 17/04138-8)