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Non-enzymatic stromal vascular fraction used to enhance bone grafting in tertiary alveolar cleft patients: a prospective, randomized and controlled clinical trial

Grant number: 21/01412-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2021
Effective date (End): July 31, 2022
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Nivaldo Alonso
Grantee:Giovanna Layse Uyeda
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Autologous bone grafting (ABG) is still considered the standard method for alveolar cleft repair. The best results of bone formatting occur when it is performed during mixed dentition (8-10y). However, there is a range of patients who don't achieve satisfactory results or don't have the proper access to the cleft treatment. When the ABG is performed later, during the permanent dentition, greater the chances of failure (~40%). In the past two decades, studies focus com tissue engineering with bone substitutes and/or bone stimulators. Since the knowledge about stromal vascular fraction and adipose derived stem cells, and their theorical capacity of tissue regeneration, great interesting emerged in many fields of medicine. The use of them is still limited in craniofacial surgery. The main goal of this study is to conduct a prospective, randomized and controlled study to stablish a more efficient method of bone graft integration for alveolar cleft patients with permanent dentition using emulsified stromal vascular fraction and iliac crest bone graft.

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