Cascade reactions for alkaloids synthesis

• Grant number: 21/02653-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2021
• End date: November 30, 2021
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Anita Jocelyne Marsaioli
• Grantee: Paulo Gabriel Massayuki Miyake Nakaya
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Alkaloids are secondary metabolites found in plants and animals displaying several biological activities making them targets for the development of new drugs. However, the big challenge is to achieve an efficient and enantioselective process to these natural products. In this way, we propose an enzymatic cascade route involving transaminases (TA), followed by a spontaneous intramolecular Aza-Michael reaction (AMR)1 to produce 2,5-disubstituted pyrrolidines.