Nanodelivering of magnetically confined Buparvaquone: a Leishmaniose drug

• Grant number: 21/05410-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2021
• End date: May 31, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Henrique Eisi Toma
• Grantee: Gustavo Melchior Ferreira
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 18/21489-1 - Supramolecular nanotechnology: design, materials and devices, AP.TEM

Abstract

Buparvaquone is leishmaniose drug which has a limited solubility in water. Its confinement and transport in lipidic nanoparticles has already been investigated. A new strategy is being proposed based on its complexation with iron(III) ions or immobilization in superparamagnetic nanoparticles.