In vitro comparative metabolomic evaluation of candidate drugs for leishmaniasis treatment

• Grant number: 12/04601-6
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): June 01, 2012
• Effective date (End): May 31, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Marina Franco Maggi Tavares
• Grantee: Gisele André Baptista Canuto
• Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Leishmaniasis is a widespread but neglected disease, the therapeutic arsenal against the disease is limited, and consists of highly toxic drugs. There is an urgent demand for new drugs to treat Leishmaniasis. Metabolome can be used to detect changes in a biological system. A variety of analytical systems, such as NMR and separation techniques GC, LC and CE (all coupled with mass-spectrometry), are used for metabolomics studies. This project intends to investigate in vitro the anti-leishmaniasis potential of natural products, such as peptides derived from amphibian skin, and to compare with comercial drugs (such as pentavalent antimonial, miltefosine and buparvaquone) for the treatment of Leishmania parasites, using a metabolomic approach in diferent analytical and complementary platforms (CE-MS and LC-MS).

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BAPTISTA CANUTO, GISELE ANDRE; DORR, FABIANE; GHILARDI LAGO, JOAO HENRIQUE; TEMPONE, ANDRE GUSTAVO; PINTO, ERNANI; PIMENTA, DANIEL CARVALHO; SIMON FARAH, JOAO PEDRO; MANSO ALVES, MARIA JULIA; MAGGI TAVARES, MARINA FRANCO. New insights into the mechanistic action of methyldehydrodieugenol B towards Leishmania (L.) infantum via a multiplatform based untargeted metabolomics approach. METABOLOMICS, v. 13, n. 5 MAY 2017. Web of Science Citations: 2.