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Influence of mechanical stress at in vitro digestion of soy protein-based delivery systems

Grant number: 20/16735-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2021
Effective date (End): February 28, 2022
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Engineering
Principal Investigator:Rosiane Lopes da Cunha
Grantee:Fernando Divino de Oliveira Júnior
Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Bioactive compounds, such as resveratrol, are capable to provide health benefits, however, they need to be carried in colloidal matrices to allow their controlled release in the gastrointestinal tract (GIT) and improve their bioacessibility and bioavailability. In vitro digestibility assays have been employed for this purpose, as an alternative to in vivo approaches, due to the lack of ethical restrictions, greater experimental ease, low cost, in addition to good reproducibility. Static in vitro methodologies are the most applied, as they accurately reproduce the biochemical parameters of digestion. Besides that, dynamics aspects of digestion, such as peristaltism, nutrient absorption and continuous flow of the digesta are neglected. Thus, dynamic in vitro assays that are able to reproduce one or more of these aspects should provide realistic information on the digestion process. In that way, this work aims to build and validate a gastric dynamic prototype, based on the TIM-1 model. Another aspect to be addressed is the development of carriers based on liquid and gelled emulsions stabilized by soy protein isolate. Such delivery systems will be produced by different strategies, in order to evaluate the effect of the carrier structure on digestibility. These results will provide insights for the development of colloidal systems that allow greater bioaccessibility of resveratrol. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA JUNIOR, FERNANDO DIVINO; CUNHA, ROSIANE LOPES. Soy protein-based delivery systems as carriers of trans-resveratrol: Bioaccessibility using different in vitro digestion models. Food Research International, v. 161, p. 12-pg., . (20/16735-3, 19/27354-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
OLIVEIRA JÚNIOR, Fernando Divino de. Influence of mechanical forces on in vitro digestion of soy protein-based delivery systems. 2022. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia de Alimentos Campinas, SP.

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