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Virological characterization of Brazilian SARS-CoV-2 isolates and their neutralization capabilities by serum from previously infected and/or vaccinated individuals

Grant number: 21/05661-1
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): July 01, 2021
Status:Discontinued
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Luiz Mário Ramos Janini
Grantee:Robert Andreata Santos
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated research grant:20/08943-5 - Investigation of the hosts' induced elements in response to the immunisation with ChAdOx1 nCOV-19 vaccine in a Phase III Clinical Trial, AP.TEM
Associated scholarship(s):23/02345-7 - Evaluation of SARS-CoV-2 escape mutants generated after incubation with antibodies raised by different immunization protocols, BE.EP.PD

Abstract

The postdoctoral fellow to participate in this thematic project must have intellectual participation and work capacity to develop the central objectives of the project "Virological characterization of Brazilian isolates of SARS-CoV-2 and their capacity for neutralization by serum of previously infected individuals and /or vaccinated". In this project, it is of fundamental importance to monitor the different variants of SARS-CoV-2 isolated in Brazil, comparing them in different cell lines. Based on these accurate and real-time analyses, we will look at the dynamics of different isolates against sera from previously infected and/or vaccinated individuals. The associated data will be analyzed regarding the capacity of neutralizing the variants and a possible vaccine escape, prospecting elementary measures for the improvement of future therapeutic mechanisms. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANDREATA-SANTOS, ROBERT; JANINI, LUIZ M. R.; DURAES-CARVALHO, RICARDO. From Alpha to Omicron SARS-CoV-2 variants: What their evolutionary signatures can tell us?. Journal of Medical Virology, . (21/03684-4, 19/01255-9, 21/05661-1, 20/08943-5)
ANDREATA-SANTOS, ROBERT; MACHADO, RAFAEL RAHAL GUARAGNA; DOS SANTOS ALVES, RUBENS PRINCE; SALES, NATIELY SILVA; SOARES, CAMILA PEREIRA; RODRIGUES, KARINE BITENCOURT; SILVA, MARIANGELA OLIVEIRA; FAVARO, MARIANNA TEIXEIRA DE PINHO; RODRIGUES-JESUS, MONICA JOSIANE; YAMAMOTO, MARCIO MASSAO; et al. Validation of Serological Methods for COVID-19 and Retrospective Screening of Health Employees and Visitors to the Sao Paulo University Hospital, Brazil. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 12, p. 8-pg., . (20/08943-5, 16/20045-7, 21/05661-1, 14/50890-5, 16/23560-0, 15/02352-7, 20/06409-1, 17/24769-2, 16/14344-1, 18/23680-0, 20/10700-3, 18/07629-5, 18/07142-9)
RODRIGUES-JESUS, MONICA JOSIANE; FAVARO, MARIANNA TEIXEIRA DE PINHO; VENCESLAU-CARVALHO, ALEXIA ADRIANNE; DE CASTRO-AMARANTE, MARIA FERNANDA; ALMEIDA, BIANCA DA SILVA; SILVA, MARIANGELA DE OLIVEIRA; ANDREATA-SANTOS, ROBERT; BARBOSA, CECILIA GOMES; BRITO, SAMANTHA CARVALHO MAIA; FREITAS-JUNIOR, LUCIO H.; et al. Nano-multilamellar lipid vesicles promote the induction of SARS-CoV-2 immune responses by a protein-based vaccine formulation. Nanomedicine-Nanotechnology Biology and Medicine, v. 45, p. 11-pg., . (20/10700-3, 20/08943-5, 16/23560-0, 20/05204-7, 21/05661-1)

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