Study of antiviral activity against SARS-CoV-2 OF copper nanoparticles and copper oxide supported in kefiran

• Grant number: 21/06128-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: September 01, 2021
• End date: June 30, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Lucia Helena Mascaro Sales
• Grantee: Gleison Neres Marques
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated research grant: 13/07296-2 - CDMF - Center for the Development of Functional Materials, AP.CEPID
• Associated scholarship(s): 23/04376-7 - Development of food packaging with antimicrobial properties using nanocomposites based on biopolymers and metallic nanoparticles, BE.EP.DR

Abstract

Copper nanoparticles (NPs) (CuNPs) and copper oxide (CuONPs) have antiviral and antimicrobial properties against various types of microorganisms and low production cost. Because of this, these NPs have been used in tests against SARS-CoV-2, the virus that causes COVID-19. It is currently known that transmission of bacteria and viruses, such as SARS-CoV-2, can occur due to the transport and use of contaminated food packaging. To this end, the development of packaging using polymers with antibacterial properties has grown a lot in recent years. In particular, the use of natural polymers has attracted attention due to the reduction of environmental impacts related to their disposal. With these motivations, the present work aims to synthesize CuNPs and CuONPs and to test the antimicrobial and virucidal activity of these NPs, pure and inserted in natural kefiran films, against Staphylococcus aureus and Escherichia coli bacteria and also against the SARS-CoV-2 virus. It is also intended to carry out mechanical and cytotoxicity tests of the films. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RIBEIRO, M. H. DA SILVA; MARQUES, G. N.; MOREIRA, A. J.; OLIVEIRA, M. M.; OLIVEIRA, R. C.; DA SILVA, R. T.; KROHLING, A. C.; MACEDO, W. A. A.; BERNARDI, M. I. B.; MASCARO, L. H.; et al. Green-assisted synthesis of highly defective nanostructured Fe-doped SnO2: Magnetic and photocatalytic properties evaluation. ACTA MATERIALIA, v. 277, p. 15-pg., 2024-07-21. (13/07296-2, 21/06128-5, 22/06219-3, 23/04376-7)

MARQUES, GLEISON N.; MOREIRA, AILTON JOSE; NOBREGA, ERYKA THAMYRIS D.; BRAGA, SANDALENE; ARGENTIN, MARCELA N.; CAMARGO, ILANA L. B. DA CUNHA; AZEVEDO, EMILIO; PEREIRA, ERNESTO C.; BERNARDI, MARIA INES B.; MASCARO, LUCIA H.. Selective inhibitory activity of multidrug-resistant bacteria by zinc oxide nanoparticles. JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING, v. 12, n. 1, p. 13-pg., 2024-01-13. (22/06219-3, 13/07296-2, 21/06128-5, 22/05254-0, 13/07600-3, 22/07984-5)

FERREIRA, DAVI S.; MARQUES, GLEISON N.; FERREIRA, ADRIANADAS MERCES P.; OLIVEIRA, MARCELO M.; DA ROCHA, CLAUDIA Q.; MOREIRA, AILTON J.; FERNANDES, CARLOS H. M.; LANZA, MARCOS R.; BERNARDI, MARIA INES B.; MASCARO, LUCIA H.; et al. Synthesis of hematite (α-Fe2O3) nanoparticles using Syzygium cumini extract: Photodegradation of norfloxacin and enhanced recyclability. Materials Chemistry and Physics, v. 332, p. 12-pg., 2024-12-20. (18/22210-0, 23/06558-5, 23/07525-3, 19/06650-3, 18/22022-0, 18/09761-8, 21/06128-5, 23/01425-7, 22/12895-1, 22/06219-3, 13/07296-2, 18/22211-7)

MARQUES, GLEISON N.; REIS, ROBERTA Y. N.; RIBEIRO, LARA K.; SIMOES, LUIZ G. P.; MINOZZI, DANIEL T.; ANDRES, JUAN; ASSIS, MARCELO; MASCARO, LUCIA H.; LONGO, ELSON. Antiviral leather: A functional coating based on SiO2-AgNPs to eliminate pathogens. JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING, v. 11, n. 5, p. 8-pg., 2023-10-01. (13/07296-2, 21/06128-5, 21/11326-0)

MOREIRA, AILTON J.; BLASKIEVICZ, SIRLON F.; DE ASSIS, MARCELO; MARQUES, GLEISON N.; MENEZES, WALLAS T.; RABELLO, PIETRA T.; RABAHI, CESAR; GOBATO, YARA G.; FRESCHI, GIAN P. G.; MASCARO, LUCIA H.; et al. Effect of synthesis methods of Co-modified TiO₂ in its photocatalytic and bactericidal activity. RESEARCH ON CHEMICAL INTERMEDIATES, v. 50, n. 1, p. 26-pg., 2023-10-13. (13/07296-2, 17/11986-5, 21/06128-5)

PATROCINIO, KATIANA L.; MARQUES, GLEISON N.; GOUVEIA, AMANDA F.; RIBEIRO, LARA K.; PINHEIRO, NAYARA A.; BERNARDI, MARIA I. B.; ANDRES, JUAN; LONGO, ELSON; ASSIS, MARCELO. Blue pigment based on Ni-doped Zn2GeO4: Addressing structure and electronic properties by combining experiment and theory. CERAMICS INTERNATIONAL, v. 50, n. 18, p. 11-pg., 2024-07-28. (23/12399-7, 13/07296-2, 21/06128-5)

LIMA, JULIANA B.; MARQUES, GLEISON N.; FERREIRA, DAVI S.; MOREIRA, AILTON. J.; ASSIS, MARCELO; LONGO, ELSON; BERNARDI, MARIA INES B.; RANGEL, JOSE H. G.; AZEVEDO, EMILIO; MASCARO, LUCIA H.; et al. Degradation of emerging contaminants using Co/Nb-modified SnO₂ nanoparticles and produced with babassu mesocarp (Orbgnya Speciosa). JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING, v. 13, n. 2, p. 14-pg., 2025-03-04. (22/06219-3, 21/06128-5)