Effect of statherin-derived peptide (Stn15pSpS) on the thickness and morphology of the acquired enamel pellicle: evaluation by transmission electron microscopy

• Grant number: 21/09013-4
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: December 15, 2021
• End date: May 14, 2022
• Field of knowledge: Health Sciences - Dentistry - Social and Preventive Dentistry
• Principal Investigator: Marília Afonso Rabelo Buzalaf
• Grantee: Fabiana Navas Reis
• Supervisor: Matthias Hannig
• Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
• Institution abroad: Saarland University, Homburg, Germany
• Associated to the scholarship: 20/01634-7 - Effect of a statherin-derived peptide (Stn15pSpS) on the prevention of erosive wear of enamel and dentine in vitro, BP.MS

Abstract

The acquired pellicle (AP) is a film that results from selective adsorption of proteins, glycoproteins and lipids on the tooth surface. The AP forms a protective interface on the tooth surface that reduces the demineralizing effects of acids. Recently, a statherin-derived peptide (Stn15pSpS) was shown to protect against initial enamel erosion in vitro and in vivo. However, the exact mechanisms by which the protection occurs are not known so far. Thus, the aim of this study will be to provide additional insights into the mechanisms of dental protection by treatment with Stn15pSpS by evaluating the thickness and morphology of the AP formed on the tooth surface after treatment with this peptide.