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Vascular regenerative MAA-based material film on antimicrobial [PAA/PLL]10/TC/anionic B-CD coating for percutaneous implants devices

Grant number: 21/10762-1
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): October 01, 2021
Effective date (End): January 31, 2024
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Érica Dorigatti de Avila
Grantee:Marta Maria Alves Pereira
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated research grant:18/20719-3 - A novel antimicrobial drug-delivery coating for percutaneous implant devices, AP.JP


Antimicrobial coatings on Percutaneous Devices (PDs), such as dental implants and exposed pins, are considered an effective strategy to avoid infection progression that might result in PD loss. Our conducted preliminary research validated the tetracycline incorporation method into the layer-by-layer system, assembled by alternating polyelectrolyte layers of poly(acrylic acid) (PAA) and poly(l-lysine) (PLL), through the synthesis of tetracycline (TC) with anionic beta cyclodextrin (B-CD). The succeeded [PAA/PLL]10/TC/anionic B-CD biomaterial coating showed to be readily tunable to different physiological scenarios, with a controlled release of the drug up to 30 days. Antibacterial effect of [PAA/PLL]10/TC/anionic B-CD was confirmed against Staphylococcus aureus ATCC 25923. The exciting outcomes encouraged us to proceed with the studies and translate the power of antimicrobial multilayer systems in meaningful biomedical applications. Herein, taking into consideration the importance of tissue quality surrounding PDs and the need to protect the drug into the multilayers, in this project, we will focus on the development of acidic pH sensible film with methacrylic acid (MAA)-based vascular regenerative to cover [PAA/PLL]10/TC/anionic B-CD and to promote vascularization and subsequent wound healing. A detailed multilayer coating characterization will be performed by different microscopy and spectroscopy approaches to probe physical and chemical properties. Coating stability of MAA-film on [PAA/PLL]10/TC/anionic B-CD system will be confirmed under neutral and acidic pH, mimicking healthy and diseased/inflammatory environments, respectively. Moreover, the molecular and cellular mechanisms of interaction in the presence of MAA-film will be investigate to improve the therapeutic effect of layer-by-layer coating system. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MIRANDA, LUIS FERNANDO B.; LIMA, CAROLINA V.; PAGIN, RAFAELA; COSTA, RAPHAEL C.; PEREIRA, MARTA MARIA A.; DE AVILA, ERICA D.; BERTOLINI, MARTINNA; RETAMAL-VALDES, BELEN; SHIBLI, JAMIL A.; FERES, MAGDA; et al. Effect of Processing Methods of Human Saliva on the Proteomic Profile and Protein-Mediated Biological Processes. JOURNAL OF PROTEOME RESEARCH, v. 22, n. 3, p. 14-pg., . (21/09434-0, 18/20719-3, 20/10436-4, 21/10762-1)

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