Effect of global or conditional deletion (skeletal muscle) of the Nr1d1 gene on aging

• Grant number: 21/08693-1
• Support type: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): October 01, 2021
• Effective date (End): September 30, 2023
• Field of knowledge: Health Sciences - Physical Education
• Principal researcher: Adelino Sanchez Ramos da Silva
• Grantee: Ana Paula Pinto
• Home Institution: Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 19/11820-5 - Nr1d1 function on the aging-associated Sarcopenia, AP.TEM

Abstract

Rev-erb-alpha is an important physiological regulator of autophagy, mitochondrial content, oxidative function, and maintenance of skeletal muscle mass, making this protein a promising molecular target for the prevention and treatment of sarcopenia. However, studies in the scientific literature were carried out in rodents with global Nr1d1 deletion, which makes it impossible to differentiate between systemic and local functions of rev-erb-alpha in skeletal muscle physiology. Thus, the application of experimental conditional knockout models is crucial for mechanistic advances regarding the role of the rev-erb-alpha protein in aging-associated sarcopenia. Therefore, the general objective of this project will be to verify the role of the global or specific (skeletal muscle) deletion of Nr1d1 in the aging process. (AU)