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Evaluation of the biocompatibility and biomineralization capacity of an experimental mineral trioxide aggregate

Grant number: 21/10027-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2021
Effective date (End): October 31, 2022
Field of knowledge:Health Sciences - Dentistry - Endodontics
Principal Investigator:Eloi Dezan Junior
Grantee:Gustavo Ramos Schiavetti
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Mineral trioxide aggregate (MTA) was developed to seal iatrogenic or pathological communication, with a hydrophilic nature that allows its use even in the presence of moisture. Characteristics such as biocompatibility and mineralized tissue deposition (biomineralization) are fundamental for this class of repair cements. The present study aims to evaluate the inflammatory response and mineralization induction of an experimental MTA (Indusbello, Londrina PR) in comparison with the positive controls MTA Angelus, MTA Repair HP and BIO-C Repair. Thirty Wistar rats will be used, which will receive subcutaneous polyethylene tube implants containing the test materials and an empty tube as a control (n=10 animals/period). After 7, 30 and 60 days, the animals will be euthanized and the polyethylene tubes removed with the adjacent tissues. Inflammatory infiltrate and fibrous capsule thickness will be evaluated histologically by hematoxylin and eosin staining by assigning inflammatory scores (scores 0, 1, 2 and 3), according to the intensity of inflammation. The presence or absence of mineralized tissue will be evaluated by Von Kossa staining and without staining for analysis under Polarized Light. Data will be tabulated and submitted to a statistical test with a significance of 5% (P<.05). (AU)

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