Development of electrochemical devices based on graphene obtained by advanced inkjet-printing and laser-scribing techniques as platforms to monitor biomarkers

• Grant number: 21/14732-0
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: April 01, 2022
• End date: March 31, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Lauro Tatsuo Kubota
• Grantee: Patrícia Batista Deroco
• Supervisor: Arben Merkoci
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: Catalan Institute of Nanoscience and Nanotechnology (ICN2), Spain
• Associated to the scholarship: 19/00166-2 - Paper-Based Electrochemical Biosensor for Traumatic Brain Injury detection, BP.PD

Abstract

The COVID-19 outbreak showed us the need for improvement and new, simpler and more practical diagnostic technologies. In this sense, the combination of advanced materials such as graphene and its derivatives with automated techniques for obtaining electrodes, as well as inkjet printing and laser-scribing, can generate devices without the need for additional modifications to the printed electrochemical sensors. This is because graphene provides highly conductive and flexible films and its functional groups facilitate direct covalent binding with bioreceptor via carbodiimide coupling. However, one of the main challenges of printing with pure graphene is the tendency of the material to aggregate, once it is difficult to disperse it in liquids with the necessary properties for inkjet printing. This leads to the development of new inkjet ink formulations and the application of new technologies to obtain more practical, cheaper and easier-to-use graphene-based electrodes, mainly aiming to break the academic research barrier to make such devices marketable. Thus, this project aims to development of new formulation of graphene-based ink and to apply advanced and automated inkjet printing and laser scribing technologies in the fabrication of a platform to employ in high-sensitivity electrochemical biosensors. The immobilization of biological materials on the sensor surface will allow the development of a biosensor for monitoring the microbiome, as a novel diagnostic strategy for customized medicine. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DEROCO, PATRICIA BATISTA; WACHHOLZ JUNIOR, DAGWIN; KUBOTA, LAURO TATSUO. Paper-based Wearable Electrochemical Sensors: a New Generation of Analytical Devices. Electroanalysis, v. N/A, p. 12-pg., 2022-06-28. (21/14732-0, 14/50867-3, 13/22127-2, 19/00166-2, 21/09706-0)