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Influence of omega-3 fatty acid supplementation on the repair process after late tooth replantation

Grant number: 21/12881-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2022
Effective date (End): April 30, 2023
Field of knowledge:Health Sciences - Dentistry - Endodontics
Principal researcher:Luciano Tavares Angelo Cintra
Grantee:Vitória Marques Gomes
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Dental avulsion is one of the most severe injuries caused by trauma. Dental reimplantation is the treatment of choice for this case and one of its consequences is the possibility of ankylosis and root resorption. This work aims to analyze the effects of using omega-3 fatty acid in the repair process after late tooth replantation. For this, 40 Wistar rats will be used, which will be divided into 4 groups (n=10), namely: Group C30 (control 30 days), Group C60 (control 60 days), Group O30 (supplemented with omega-3 for 30 days) and Group O60 (supplemented for 60 days). Supplementation with omega-3 will be done through gavage, which will start after dental reimplantation, having total duration according to the supplementation time of each group. The animals will have the upper right incisors avulsed and treated in accordance with the International Association of Dental Traumatology protocol for delayed dental replantation. After the supplementation period, the animals will be euthanized and the hemimaxillas removed and processed for microtomographic analysis to quantify the extent of root and histological resorption in hematoxylin and eosin (HE), and immunohistochemistry by IL-6, TNF- ± and TRAP. Data will be analyzed by specific statistical tests for each case, with a significance level of 5% (p<0.05). (AU)

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