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Osteoporosis diagnosis through multiscale modeling of bone fracture using the boundary element method, molecular dynamics, and other computational methods

Grant number: 22/03410-4
Support type:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): August 01, 2022
Effective date (End): July 31, 2023
Field of knowledge:Engineering - Mechanical Engineering - Mechanics of Solids
Principal researcher:Munir Salomao Skaf
Grantee:Amadeus Cavalcanti Salvador de Alcântara
Supervisor abroad: Markus J. Buehler
Home Institution: Faculdade de Engenharia Mecânica (FEM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Research place: Massachusetts Institute of Technology (MIT), United States  
Associated to the scholarship:18/18503-2 - Osteoporosis diagnosis through multiscale modeling of bone fracture using the boundary element method and molecular dynamics, BP.DD

Abstract

Osteoporosis-induced bone fracture is a major health concern. The rising average life expectancy implies that a greater fraction of the population will be afflicted by osteoporosis, a chronic condition which decreases bone toughness and increases fracture risk by deteriorating tissue structure from the molecular to the macroscopic length scale. If current medical diagnosis technologies remain unimproved, osteoporosis-induced bone fracture will become a heavier social and financial burden for health care systems worldwide. By identifying bone structure failure criteria and correlating them to early signs of tissue deterioration, predictive diagnosis will be improved. A novel approach is proposed to the early diagnosis of fracture in osteoporotic bone tissue: the 3D multiscale modeling and simulation of osteoporosis-induced bone fracture using the Boundary Element Method, Molecular Dynamics, and other Computational Methods. Since the simulation domain is defined from Computed Tomography data, simulation analysis produces patient-specific bone fracture risk analysis. (AU)

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