Multiscale modeling and optimization of additively manufactured composite bone imp...
| Grant number: | 18/18503-2 |
| Support type: | Scholarships in Brazil - Doctorate (Direct) |
| Effective date (Start): | March 01, 2019 |
| Effective date (End): | November 30, 2021 |
| Field of knowledge: | Engineering - Biomedical Engineering - Bioengineering |
| Principal Investigator: | Paulo Sollero |
| Grantee: | Amadeus Cavalcanti Salvador de Alcântara |
| Home Institution: | Faculdade de Engenharia Mecânica (FEM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
Abstract Osteoporosis-induced bone fracture is a major health concern. The rising average life expectancy implies that agreater fraction of the population will be afflicted by Osteoporosis, a chronic condition which decreases bonetoughness and increases fracture risk by deteriorating tissue structure from the molecular to the macroscopiclength scale. If current medical diagnosis technologies remain unimproved, Osteoporosis-induced bone fracturewill become a heavier social and financial burden for health care systems worldwide. By identifying bonestructure failure criteria and correlating them to early signs of tissue deterioration, predictive diagnosis willbe improved. A novel approach is proposed to the early diagnosis of fracture in osteoporotic bone tissue: the 3D multiscale modeling and simulation of Osteoporosis-induced bone fracture using the boundary element method and molecular dynamics. Since the simulation domain is defined from computed tomography data, simulation analysis produces patient-specific bone fracture risk analysis. (AU) | |