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Osteoporosis diagnosis through multiscale modeling of bone fracture using the boundary element method and molecular dynamics

Grant number: 18/18503-2
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2019
Effective date (End): November 30, 2021
Field of knowledge:Engineering - Biomedical Engineering - Bioengineering
Principal researcher:Paulo Sollero
Grantee:Amadeus Cavalcanti Salvador de Alcântara
Home Institution: Faculdade de Engenharia Mecânica (FEM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Osteoporosis-induced bone fracture is a major health concern. The rising average life expectancy implies that agreater fraction of the population will be afflicted by Osteoporosis, a chronic condition which decreases bonetoughness and increases fracture risk by deteriorating tissue structure from the molecular to the macroscopiclength scale. If current medical diagnosis technologies remain unimproved, Osteoporosis-induced bone fracturewill become a heavier social and financial burden for health care systems worldwide. By identifying bonestructure failure criteria and correlating them to early signs of tissue deterioration, predictive diagnosis willbe improved. A novel approach is proposed to the early diagnosis of fracture in osteoporotic bone tissue: the 3D multiscale modeling and simulation of Osteoporosis-induced bone fracture using the boundary element method and molecular dynamics. Since the simulation domain is defined from computed tomography data, simulation analysis produces patient-specific bone fracture risk analysis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALCANTARA, AMADEUS C. S.; ASSIS, ISRAEL; PRADA, DANIEL; MEHLE, KONRAD; SCHWAN, STEFAN; COSTA-PAIVA, LUCIA; SKAF, MUNIR S.; WROBEL, LUIZ C.; SOLLERO, PAULO. Patient-Specific Bone Multiscale Modelling, Fracture Simulation and Risk Analysis-A Survey. MATERIALS, v. 13, n. 1 JAN 1 2020. Web of Science Citations: 2.

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