Antimicrobial effect and mechanical properties of ultra-translucent zirconia coated by experimental glasses

• Grant number: 22/03273-7
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: August 01, 2022
• End date: January 31, 2023
• Field of knowledge: Health Sciences - Dentistry - Dental Materials
• Principal Investigator: Renata Marques de Melo Marinho
• Grantee: Clarice Ferreira Sabino
• Supervisor: Vinicius Rosa
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil
• Institution abroad: National University of Singapore (NUS), Singapore
• Associated to the scholarship: 21/00748-1 - Mechanical and antimicrobial properties of translucent zirconia covered by silver silicate or silvered glaze, BP.MS

Abstract

Associated with the process #2021/00748-1, in which the analysis of mechanical and antimicrobial properties of ultra-translucent zirconia with different vitreous coating is proposed, the present project applies for a six-month research internship in the National University of Singapore. Zirconia is a ceramic material commonly used in dentistry because of its high fracture toughness value, besides its biocompatibility, aesthetics, and mechanical resistance. This material, when clinically exposed to the oral environment, undergo low temperature degradation, which can reduce its mechanical strength, being sped up by micro-crack and affecting its surface roughness, which makes it also highly prone to superficial biofilm adhesion. A common procedure during zirconia's final processing is the application of a vitreous coating, enhancing the zirconia's mechanical properties. Therefore, the aim of this project is to complement the mechanical and antimicrobial properties analysis of the ultra-translucent zirconia 5Y-PSZ infiltrated by different glasses. 85 samples of UTML ultra-translucent zirconia (KATANA ", Kuraray Noritake Dental Inc, Tokyo, Japan) will be used, divided into 4 groups: ZR polished; ZR Glazed; ZR with silver glass; ZR with boron glass. The specimens will be subjected to Crystal violet assay, XTT reduction assay, confocal laser scanning microscopy, atomic force microscope, wettability, and Ion release tests. The expected result is to prove that UTML zirconia infiltrated with experimental glasses has less biofilm surface adhesion than glazed and polished surfaces, besides having antimicrobial activity against specific microorganisms and better mechanical properties. (AU)