Evaluation of the effect of heterotypic signaling on tumor phenotype modulation in Melanoma

• Grant number: 21/05087-3
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: July 01, 2022
• End date: October 31, 2026
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: André Zelanis Palitot Pereira
• Grantee: Uilla Barcick
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil

Abstract

Melanoma is a type of Skin Cancer that can progress according to multifactorial disorders. The ability of Melanoma cells to invade and metastasize to organs distant from the body suggests their adaptability to different microenvironments. The imbalance of cellular homeostasis during oncogenesis together with the high heterogeneity of stromal cells associated with the tumor have a marked effect on the repertoire of proteins secreted by malignant cells. The metastatic potential of cancer cells is determined by factors that include the cells within the tumor microenvironment (tumor and stromal cells), as well as the factors released by these different cell populations. In this context, endothelial cells actively participate in the secretion of angiogenic factors that promote tumor growth and progression, in addition to secreting factors that enable the migration of tumor cells. Thus, the main objective of this project is to identify molecular patterns associated with the cross-talk of endothelial and tumor cells that contribute to the development and establishment of the pre-metastatic niche, as well as to its organotropism in Melanoma. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RACORTI, NATHALIA DE VASCONCELLOS; MARTINELLI, MATHEUS; BUSTOS, SILVINA ODETE; SALARDANI, MURILO; CAMACHO, MAURICIO FROTA; BARCICK, UILLA; LIMA, LUIS ROBERTO FONSECA; JEDLICKA, LETICIA DIAS LIMA; DE CAMPOS, CLAUDIA BARBOSA LADEIRA; VALENTE, RICHARD HEMMI; et al. "Mannose-6-Phosphate Isomerase Functional Status Shapes a Rearrangement in the Proteome and Degradome of Mannose-Treated Melanoma Cells" (vol 23,pg 5177, 2024). JOURNAL OF PROTEOME RESEARCH, v. N/A, p. 1-pg., 2024-11-26. (21/05087-3, 22/15421-0, 19/10855-0, 23/05715-0)

SALARDANI, MURILO; BARCICK, UILLA; ZELANIS, ANDRE. Proteolytic signaling in cancer. EXPERT REVIEW OF PROTEOMICS, v. 20, n. 12, p. 11-pg., 2023-10-29. (21/05087-3, 22/15421-0)

ZELANIS, ANDRE; BARCICK, UILLA; RACORTI, NATHALIA DE VASCONCELLOS; SALARDANI, MURILO. Heterotypic communication as the promoter of phenotypic plasticity of cancer cells: The role of cancer secretomes. PROTEOMICS, v. N/A, p. 10-pg., 2023-07-20. (21/05087-3, 19/07282-8)