Characterization of APC5 loss-of-function mutants in Arabidopsis thaliana

• Grant number: 22/07736-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2022
• End date: May 31, 2024
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Agreement: Max Planck Society for the Advancement of Science
• Principal Investigator: Nubia Barbosa Eloy
• Grantee: Giovana Silvestrini Cotrin
• Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
• Associated research grant: 17/10333-8 - APC as an entry point to study small molecule regulation of the cell cycle, AP.JP

Abstract

The Anaphase Promoter Complex (APC) is a multiprotein complex - an E3 ubiquitin ligase - involved in ubiquitin-dependent proteolysis of cell cycle regulatory proteins, which include the destruction of mitotic cyclins during the transition of metaphase to anaphase. Identification of the complete set of genes encoding the subunits of the APC in Arabidopsis, suggests that the basic processes controlled by ubiquitin-mediated proteolysis in plants are similar to those of other organisms. However, results from several groups indicate that the APC has other specific functions in the regulation of plant development. (AU)