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Structure-property correlation and antimicrobial effect of semiconductor addition to acrylic resins

Grant number: 22/01344-4
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): September 01, 2022
Effective date (End): May 14, 2023
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal Investigator:Andréa Cândido dos Reis
Grantee:Beatriz Danieletto Sahm
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The formation of biofilm on the surfaces of prostheses can lead to local diseases, in addition to systemic diseases. These factors limit the longevity of rehabilitative treatment and the quality of life of patients. However, it is desirable to provide a material that promotes the antimicrobial capacity, providing it with reduced accumulation of microorganisms and ideal physical-mechanical properties. Due to the antimicrobial potential of silver vanadate (²-AgVO3) and reduced graphene oxide (OGr), this study proposes to develop materials based on polymethylmethacrylate incorporated with antimicrobials for the manufacture of prostheses and to evaluate them in terms of their physical-mechanical and microbiological properties. . The semiconductors will be incorporated into acrylic resin specimens at different concentrations previously determined. Initially, the minimum inhibitory concentration (MIC) of materials against Candida albicans, Pseudomonas aeruginosa, Streptococcus mutans, and Staphylococcus aureus species will be evaluated. Then, specimens will be made in thermopolymerizable and self-curing acrylic resin divided into groups G1 (thermo-polymer resin + ²-AgVO3); G2 (Thermo resin + OGr); G3 (auto resin + ²-AgVO3); G4 (Auto resin + OGr). The antimicrobial properties will be evaluated by the XTT reduction method, colony-forming unit count (CFU) and confocal microscopy, scanning electron microscopy (SEM). The microstructural characterization will be performed by scanning electron microscopy (SEM), energy dispersive elemental analysis (EDS), and Differential Scanning Calorimetry (DSC). The physical-mechanical tests will evaluate sorption and solubility, roughness, hardness, flexural strength, surface degradation, wettability, radiopacity, porosimetry, mass loss by wear challenge, and acid challenge. Data will be statistically analyzed depending on their distribution pattern.Keywords: Acrylic resin; Antimicrobials; Semiconductors.

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