Optimization of Leading Compounds for the Treatment of Tropical Parasitic Diseases in Collaboration with the Drugs for Neglected Diseases Initiative (DNDi)

• Grant number: 22/13110-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2023
• End date: September 30, 2024
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Luiz Carlos Dias
• Grantee: João Pedro Nogueira Bonesconto
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery, AP.CEPID

Abstract

The objective of the project is to continue the search for pharmacological innovations for the treatment of neglected diseases, especially CD and Leishmaniasis, through the synthesis of new analogues of target molecules sent by DNDi, as starting points. It is expected that the synthesized compounds will be able to progress in the drug development chain, reaching a suitable profile for a candidate, and that in the future they may promote the treatment of CD and Leishmaniasis, and thus control these prevalent and consequential diseases. disastrous in patients where the lack of effective and safe therapies manifests itself in a disabling way.